Repetitive Transcranial Magnetic Stimulation

NCT ID: NCT00169689

Last Updated: 2008-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-06-30

Study Completion Date

2007-08-31

Brief Summary

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The study is a prospective, randomized, double-blind sham-controlled study.

Detailed Description

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The principal objective of this trial is to investigate the effect of left prefrontal high frequency rTMS on negative symptoms in schizophrenia.

Conditions

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Schizophrenia

Keywords

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schizophrenia, rTMS

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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rTMS

sham coil system versus verum rTMS stimulation

Group Type SHAM_COMPARATOR

rTMS, "repetitive transcranial magnetic stimulation"

Intervention Type PROCEDURE

10 Hz rTMS (10.000 stimuli) over left dorsolateral prefrontal cortex

rTMS

Intervention Type OTHER

repetitive transcranial magnetic stimulation, 10 Hz, 10.000 stimuli, 2 weeks

Interventions

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rTMS, "repetitive transcranial magnetic stimulation"

10 Hz rTMS (10.000 stimuli) over left dorsolateral prefrontal cortex

Intervention Type PROCEDURE

rTMS

repetitive transcranial magnetic stimulation, 10 Hz, 10.000 stimuli, 2 weeks

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* DSM-IV criteria for schizophrenia
* age between 18 and 60
* informed consent
* right handed patient
* no change of antipsychotic treatment \> 2 weeks before recruitment

Exclusion Criteria

* seizures, epilepsy
* history of severe head injury
* status post implantation of a cardiac pacemaker or other electronic devi-ses
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Heinrich-Heine University, Duesseldorf

OTHER

Sponsor Role lead

Responsible Party

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Heinrich-Heine University

Principal Investigators

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Joachim Cordes, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Psychiatry and Psychotherapy at the Heinrich-Heine-University Düsseldorf,Rhineland State Clinics Düsseldorf, Bergische Landstraße 2, 40629 Düsseldorf, Germany

PD Dr. W Wölwer

Role: PRINCIPAL_INVESTIGATOR

Heinrich-Heine-University

PD Dr. MW Agelink

Role: PRINCIPAL_INVESTIGATOR

Department of Psychiatry Herford

Locations

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Joachim Cordes

Düsseldorf, Rhineland, Germany

Site Status

Countries

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Germany

References

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Cordes J, Arends M, Mobascher A, Jänner M, Wölwer W, Krieger K, Agelink MW, Klimke A, Brinkmeyer J. Left prefrontal high frequency repetitive transcra-nial magnetic stimulation (rTMS) and the effect on schizophrenic psychopathol-ogy. European Archives of Psychiatry and Clinical Neuroscience 2004; Vol. 254, Suppl. 1: 11. Cordes J, Brinkmeyer J, Kotrotsios G, Arends M, Mobascher A, Agelink MW, Wölwer W. The effect of high frequency repetitive transcranial magnetic stimula-tion (rTMS) on negative symptoms and electrophysiological correlates of facial affect recognition in schizophrenia. Schizophrenia Bulletin 2005 b; 31 (2): 510.

Reference Type RESULT

Wolwer W, Lowe A, Brinkmeyer J, Streit M, Habakuck M, Agelink MW, Mobascher A, Gaebel W, Cordes J. Repetitive transcranial magnetic stimulation (rTMS) improves facial affect recognition in schizophrenia. Brain Stimul. 2014 Jul-Aug;7(4):559-63. doi: 10.1016/j.brs.2014.04.011. Epub 2014 May 9.

Reference Type DERIVED
PMID: 24857264 (View on PubMed)

Cordes J, Thunker J, Agelink MW, Arends M, Mobascher A, Wobrock T, Schneider-Axmann T, Brinkmeyer J, Mittrach M, Regenbrecht G, Wolwer W, Winterer G, Gaebel W. Effects of 10 Hz repetitive transcranial magnetic stimulation (rTMS) on clinical global impression in chronic schizophrenia. Psychiatry Res. 2010 May 15;177(1-2):32-6. doi: 10.1016/j.psychres.2009.01.014. Epub 2010 Apr 8.

Reference Type DERIVED
PMID: 20378181 (View on PubMed)

Other Identifiers

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TMS_01

Identifier Type: -

Identifier Source: secondary_id

TMS_S_01

Identifier Type: -

Identifier Source: org_study_id