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Pulmonary Rehabilitation in Interstitial Lung Disease

NCT ID: NCT00168285

Last Updated: 2007-04-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

56 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-03-31

Study Completion Date

2007-05-31

Brief Summary

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Interstitial lung disease (ILD) is a highly disabling group of conditions including idiopathic pulmonary fibrosis (IPF), acute and chronic interstitial pneumonias, connective tissue diseases and sarcoidosis. People with ILD frequently experience breathlessness on exertion, which limits their ability to undertake daily activities. People with ILD report very poor quality of life due to low levels of physical functioning and vitality, and high levels of breathlessness and fatigue. There are few treatments for ILD and those that are available have limited impact on quality of life.

The aim of this study is to assess the effects of Pulmonary Rehabilitation, which consists of specialised exercise training for people with lung disease, on exercise capacity and quality of life in people with ILD. We hypothesis that exercise training will result in reduced dyspnoea, improved exercise tolerance and enhanced quality of life.

Detailed Description

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Interstitial lung disease (ILD) is a highly disabling group of conditions including idiopathic pulmonary fibrosis (IPF), acute and chronic interstitial pneumonias, connective tissue diseases and sarcoidosis. People with ILD frequently experience breathlessness on exertion, which limits their ability to undertake daily activities and reduces health-related quality of life.Available treatments for ILD have proved largely ineffective, offering no improvement in survival and demonstrating only limited impact on quality of life.

Aims of the Research

1. Evaluate the effects of Pulmonary Rehabilitation on exercise capacity and quality of life in patients with ILD
2. Determine the physiological response to Pulmonary Rehabilitation in patients with ILD
3. Determine the relationship between the aetiology and severity of ILD and the effects of Pulmonary Rehabilitation.

Comparisons: 8 weeks exercise training compared to control group (maximal exercise capacity, functional exercise capacity, dyspnoea, quality of life).

Conditions

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Interstitial Lung Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Interventions

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Pulmonary Rehabilitation

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Ambulant
* Stable medical therapy
* Dyspnoea on exertion following maximal treatment

Exclusion Criteria

* A history of syncope on exertion
* Too unwell to attend the hospital for exercise training
* Any other comorbidities which would prevent exercise training
* Previous Pulmonary Rehabilitation in the last 12 months
Minimum Eligible Age

40 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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La Trobe University

OTHER

Sponsor Role collaborator

Austin Hospital, Melbourne Australia

OTHER

Sponsor Role collaborator

Victorian Tuberculosis and Lung Association

UNKNOWN

Sponsor Role collaborator

The Alfred

OTHER

Sponsor Role lead

Principal Investigators

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Anne E Holland, PhD

Role: PRINCIPAL_INVESTIGATOR

Alfred Hospital and LaTrobe University

Matthew Conron, MBBS

Role: PRINCIPAL_INVESTIGATOR

The Alfred

Prue Munro, BAppSc

Role: PRINCIPAL_INVESTIGATOR

The Alfred

Christine McDonald, MBBS PhD

Role: PRINCIPAL_INVESTIGATOR

Austin Hospital, Melbourne Australia

Catherine Hill, PhD

Role: PRINCIPAL_INVESTIGATOR

Austin Hospital, Melbourne Australia

Locations

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Alfred Hospital

Melbourne, Victoria, Australia

Site Status

Austin Hospital

Melbourne, Victoria, Australia

Site Status

Countries

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Australia

References

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Holland AE, Hill CJ, Conron M, Munro P, McDonald CF. Short term improvement in exercise capacity and symptoms following exercise training in interstitial lung disease. Thorax. 2008 Jun;63(6):549-54. doi: 10.1136/thx.2007.088070. Epub 2008 Feb 1.

Reference Type DERIVED
PMID: 18245143 (View on PubMed)

Other Identifiers

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PRIDe

Identifier Type: -

Identifier Source: org_study_id