Efficacy and Safety of Ciclesonide in Preschool Children With Asthma (2 to 6 Years) (BY9010/M1-207)

NCT ID: NCT00163449

Last Updated: 2016-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1000 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-11-30

Study Completion Date

2007-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of the present study is to compare the efficacy of inhaled ciclesonide in pre-school children. Ciclesonide will be inhaled once daily, using one of three dose levels and tested versus placebo. The study duration consists of a baseline period (2 to 4 weeks) and a treatment period (24 weeks). The study will provide further data on safety and tolerability of ciclesonide.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Asthma

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Asthma Ciclesonide Child Pediatric

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Ciclesonide 40 µg

Group Type ACTIVE_COMPARATOR

Ciclesonide

Intervention Type DRUG

Efficacy and Safety of Ciclesonide

2

Ciclesonide 80 µg

Group Type ACTIVE_COMPARATOR

Ciclesonide

Intervention Type DRUG

Efficacy and Safety of Ciclesonide

3

Ciclesonide 160 µg

Group Type ACTIVE_COMPARATOR

Ciclesonide

Intervention Type DRUG

Efficacy and Safety of Ciclesonide

4

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Ciclesonide

Efficacy and Safety of Ciclesonide

Intervention Type DRUG

Placebo

Placebo

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Written informed consent by the parents or legal guardians of the patient
* Outpatients
* Good health with the exception of asthma
* Documented diagnosis of asthma for more than 6 months
* Use of rescue medication only or pretreatment with a controller drug

Exclusion Criteria

* Concomitant severe diseases
* Diseases contraindicated for the use of inhaled steroids
* Other relevant lung diseases causing impairment in pulmonary function
* Recurrent, episodic wheezing only
* History of life-threatening asthma
* History of any mechanical ventilation
* Clinically relevant abnormal laboratory values suggesting an unknown disease and requiring further clinical evaluation
* Premature birth (\< 32 weeks gestation)
Minimum Eligible Age

2 Years

Maximum Eligible Age

6 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

AstraZeneca AstraZeneca

Role: STUDY_DIRECTOR

AstraZeneca

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Altana Pharma/Nycomed

Campinas - SP, , Brazil

Site Status

Altana Pharma/Nycomed

Curitiba-PR, , Brazil

Site Status

Altana Pharma/Nycomed

Paraná, , Brazil

Site Status

Altana Pharma/Nycomed

Pinheiros Sao Paulo - SP, , Brazil

Site Status

Altana Pharma/Nycomed

Porto Alegre-RS, , Brazil

Site Status

Altana Pharma/Nycomed

Porto Alegre-RS, , Brazil

Site Status

Altana Pharma/Nycomed

Recife-PE, , Brazil

Site Status

Altana Pharma/Nycomed

Rio de Janeiro-RJ, , Brazil

Site Status

Altana Pharma/Nycomed

Rio Grande, , Brazil

Site Status

Altana Pharma/Nycomed

Salvador - Bahia, , Brazil

Site Status

Altana Pharma/Nycomed

Santo André-SP, , Brazil

Site Status

Altana Pharma/Nycomed

Sao Paulo - SP, , Brazil

Site Status

Altana Pharma/Nycomed

Sao Paulo-SP, , Brazil

Site Status

Altana Pharma/Nycomed

São Paulo, , Brazil

Site Status

Altana Pharma/Nycomed

São Paulo, , Brazil

Site Status

Altana Pharma/Nycomed

São Paulo, , Brazil

Site Status

Altana Pharma/Nycomed

São Paulo, , Brazil

Site Status

Altana Pharma/Nycomed

São Paulo-SP, , Brazil

Site Status

Altana Pharma/Nycomed

Berlin, , Germany

Site Status

Altana Pharma/Nycomed

Cologne, , Germany

Site Status

Altana Pharma/Nycomed

Dresden, , Germany

Site Status

Altana Pharma/Nycomed

Düsseldorf, , Germany

Site Status

Altana Pharma/Nycomed

Frankfurt, , Germany

Site Status

Altana Pharma/Nycomed

Heidelberg, , Germany

Site Status

Altana Pharma/Nycomed

Mannheim, , Germany

Site Status

Altana Pharma/Nycomed

München, , Germany

Site Status

Altana Pharma/Nycomed

Rosenheim, , Germany

Site Status

Altana Pharma/Nycomed

Wesel, , Germany

Site Status

Altana Pharma/Nycomed

Wiefelstede, , Germany

Site Status

Altana Pharma/Nycomed

Baja, , Hungary

Site Status

Altana Pharma/Nycomed

Budapest, , Hungary

Site Status

Altana Pharma/Nycomed

Budapest, , Hungary

Site Status

Altana Pharma/Nycomed

Budapest, , Hungary

Site Status

Altana Pharma/Nycomed

Debrecen, , Hungary

Site Status

Altana Pharma/Nycomed

Jászberény, , Hungary

Site Status

Altana Pharma/Nycomed

Kaposvár, , Hungary

Site Status

Altana Pharma/Nycomed

Kiskunhalas, , Hungary

Site Status

Altana Pharma/Nycomed

Miskolc, , Hungary

Site Status

Altana Pharma/Nycomed

Mosdós, , Hungary

Site Status

Altana Pharma/Nycomed

Mosonmagyaróvár, , Hungary

Site Status

Altana Pharma/Nycomed

Nyíregyháza, , Hungary

Site Status

Altana Pharma/Nycomed

Pécs, , Hungary

Site Status

Altana Pharma/Nycomed

Szeged, , Hungary

Site Status

Altana Pharma/Nycomed

Szekszárd, , Hungary

Site Status

Altana Pharma/Nycomed

Törökbálint, , Hungary

Site Status

Altana Pharma/Nycomed

Chandanwadi, Thane, , India

Site Status

Altana Pharma/Nycomed

Chennai, , India

Site Status

Altana Pharma/Nycomed

Coimbatore, , India

Site Status

Altana Pharma/Nycomed

Coimbatore, , India

Site Status

Altana Pharma/Nycomed

Coimbatore, Tamilnadu, , India

Site Status

Altana Pharma/Nycomed

Kalaburagi, , India

Site Status

Altana Pharma/Nycomed

Mumbai, , India

Site Status

Altana Pharma/Nycomed

Mumbai, , India

Site Status

Altana Pharma/Nycomed

Mumbai, Dadar (E), , India

Site Status

Altana Pharma/Nycomed

Nagpur, , India

Site Status

Altana Pharma/Nycomed

Noida, , India

Site Status

Altana Pharma/Nycomed

Pune, , India

Site Status

Altana Pharma/Nycomed

Pune, , India

Site Status

Altana Pharma/Nycomed

Eindhoven, , Netherlands

Site Status

Altana Pharma/Nycomed

Enschede, , Netherlands

Site Status

Altana Pharma/Nycomed

Hoofddorp, , Netherlands

Site Status

Altana Pharma/Nycomed

Leeuwarden, , Netherlands

Site Status

Altana Pharma/Nycomed

Nijmegen, , Netherlands

Site Status

Altana Pharma/Nycomed

Zwolle, , Netherlands

Site Status

Altana Pharma/Nycomed

Karpacz, , Poland

Site Status

Altana Pharma/Nycomed

Lublin, , Poland

Site Status

Altana Pharma/Nycomed

Opole, , Poland

Site Status

Altana Pharma/Nycomed

Poznan, , Poland

Site Status

Altana Pharma/Nycomed

Poznan, , Poland

Site Status

Altana Pharma/Nycomed

Zawadzkie, , Poland

Site Status

Altana Pharma/Nycomed

Bellville - Cape Town -, , South Africa

Site Status

Altana Pharma/Nycomed

Cape Town, , South Africa

Site Status

Altana Pharma/Nycomed

Durban, , South Africa

Site Status

Altana Pharma/Nycomed

Morningside, Sandton, , South Africa

Site Status

Altana Pharma/Nycomed

Mowbray, Cape Town, , South Africa

Site Status

Altana Pharma/Nycomed

New Redruth, Alberton, , South Africa

Site Status

Altana Pharma/Nycomed

Overport, Durban, , South Africa

Site Status

Altana Pharma/Nycomed

Panorama / RSA-Cape Town, , South Africa

Site Status

Altana Pharma/Nycomed

Pietermaritzburg, , South Africa

Site Status

Altana Pharma/Nycomed

Westville, , South Africa

Site Status

Altana Pharma/Nycomed

Wynberg, , South Africa

Site Status

Altana Pharma/Nycomed

Barcelona, , Spain

Site Status

Altana Pharma/Nycomed

Barcelona, , Spain

Site Status

Altana Pharma/Nycomed

Barcelona, , Spain

Site Status

Altana Pharma/Nycomed

El Palmar (Murcia), , Spain

Site Status

Altana Pharma/Nycomed

Elche - Alicante, , Spain

Site Status

Altana Pharma/Nycomed

Leganes (Madrid), , Spain

Site Status

Altana Pharma/Nycomed

Madrid, , Spain

Site Status

Altana Pharma/Nycomed

Madrid, , Spain

Site Status

Altana Pharma/Nycomed

Madrid, , Spain

Site Status

Altana Pharma/Nycomed

Sabadell, , Spain

Site Status

Altana Pharma/Nycomed

Seville, , Spain

Site Status

Altana Pharma/Nycomed

Valencia, , Spain

Site Status

Altana Pharma/Nycomed

Lausanne, , Switzerland

Site Status

Altana Pharma/Nycomed

Trimbach, , Switzerland

Site Status

Altana Pharma/Nycomed

Zurich, , Switzerland

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Brazil Germany Hungary India Netherlands Poland South Africa Spain Switzerland

References

Explore related publications, articles, or registry entries linked to this study.

Brand PL, Luz Garcia-Garcia M, Morison A, Vermeulen JH, Weber HC. Ciclesonide in wheezy preschool children with a positive asthma predictive index or atopy. Respir Med. 2011 Nov;105(11):1588-95. doi: 10.1016/j.rmed.2011.07.017. Epub 2011 Aug 11.

Reference Type DERIVED
PMID: 21839625 (View on PubMed)

Related Links

Access external resources that provide additional context or updates about the study.

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

BY9010/M1-207

Identifier Type: -

Identifier Source: org_study_id