Metabolic Capacity of Israeli Populations

NCT ID: NCT00162383

Last Updated: 2018-06-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

1200 participants

Study Classification

INTERVENTIONAL

Study Start Date

1995-07-31

Study Completion Date

2020-12-31

Brief Summary

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The ability to metabolize drugs varies greatly among individuals. Major fraction of this variability lies in genetic polymorphisms of genes encoding for enzymes responsible for both phase I and phase II reactions.

The purpose of this study ws to evaluate the phenotypic activity and the frequency of genetic polymorphisms in different phase II and phase I enzymes among various populations residing in Israel.

Detailed Description

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Conditions

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Healthy Volunteers

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Cocktail

Group Type EXPERIMENTAL

Debrisoquine

Intervention Type DRUG

Mephenytoin

Intervention Type DRUG

Dapsone

Intervention Type DRUG

Caffeine

Intervention Type DRUG

Interventions

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Debrisoquine

Intervention Type DRUG

Mephenytoin

Intervention Type DRUG

Dapsone

Intervention Type DRUG

Caffeine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age range 20-50
* Absence of significant disease state

Exclusion Criteria

* The presence of significant disease states
* The regular use of drugs (including birth control pills)
Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hadassah Medical Organization

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Yoseph Caraco, MD

Role: PRINCIPAL_INVESTIGATOR

Hadassah Medical Organization

Locations

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Hadassah Medical Organization

Jerusalem, , Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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Yoseph Caraco, MD

Role: CONTACT

00 972 2 6778584

Facility Contacts

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Arik Tzukert, DMD

Role: primary

00 972 2 6776095

Hadas Lemberg, PhD

Role: backup

00 972 2 6777572

Other Identifiers

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yc19551-HMO-CTIL

Identifier Type: -

Identifier Source: org_study_id

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