Genetic Liability in the Brain Morphology of Attention Deficit Hyperactivity Disorder

NCT ID: NCT00161161

Last Updated: 2005-12-30

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 90 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 1999-10-31
• Study Completion Date: 2002-12-31

Brief Summary

Attention Deficit Hyperactivity Disorder (ADHD) is a heritable psychiatric disorder with onset in childhood. Twin and adoption studies indicate that additive genetic factors explain up to 80% of the variance underlying susceptibility. The siblings of children with ADHD have a three- to fivefold increased risk of having ADHD compared to the siblings of healthy control subjects, and the risk is even greater for monozygotic twins with 50-80% concordance compared with up to 33% in dizygotic twins). As full siblings share on average 50% of their genes, even the unaffected siblings of children with ADHD would be expected to share some of the genes involved in the disorder. The neuroanatomical substrate of ADHD is becoming increasingly better defined by a growing body of evidence from imaging studies. Evidence from neuroimaging studies suggests that this disorder is associated with reductions in brain volume up to 5% in these children. In this protocol we collected MRI-scans from boys with ADHD and their unaffected siblings, as well as control subjects. In addition, cheekswabs were later collected for DNA analysis.

Conditions

Attention Deficit Hyperactivity Disorder

Keywords

ADHD; MRI; genetics

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: OTHER

Eligibility Criteria

Inclusion Criteria

1. age 7 - 18 years.

1. DSM-IV (APA, 1994) diagnosis of ADHD (combined subtype), according to DISC interview

2. scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)

1. no DSM-IV (APA,1994) diagnosis for ADHD or another disruptive disorder (ODD or CD), according to DISC interview

2. no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)

1. no DSM-IV (APA, 1994) diagnosis, according to DISC interview

2. no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)

Exclusion Criteria

1. IQ < 70

2. illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system

3. the presence of metal objects in or around the body (pacemaker, dental braces)

• Minimum Eligible Age: 7 Years
• Maximum Eligible Age: 18 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

The Dutch Brain Foundation

OTHER

Sponsor Role: collaborator

UMC Utrecht

OTHER

Sponsor Role: lead

Principal Investigators

Sarah Durston, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

RMI of Neuroscience, UMC Utrecht

Locations

UMC Utrecht

Utrecht, , Netherlands

Countries

Netherlands

References

Durston S, Hulshoff Pol HE, Schnack HG, Buitelaar JK, Steenhuis MP, Minderaa RB, Kahn RS, van Engeland H. Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings. J Am Acad Child Adolesc Psychiatry. 2004 Mar;43(3):332-40. doi: 10.1097/00004583-200403000-00016.

Reference Type: RESULT

PMID: 15076267 (View on PubMed)

Durston S, Fossella JA, Casey BJ, Hulshoff Pol HE, Galvan A, Schnack HG, Steenhuis MP, Minderaa RB, Buitelaar JK, Kahn RS, van Engeland H. Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls. Mol Psychiatry. 2005 Jul;10(7):678-85. doi: 10.1038/sj.mp.4001649.

Reference Type: RESULT

PMID: 15724142 (View on PubMed)

Other Identifiers

WOM 99/076

Identifier Type: -

Identifier Source: org_study_id