Prevention of Asthma With Levocetirizine (36 Month Treatment) in Young Children Suffering From Eczema (Atopic Dermatitis) and Sensitized to Grass Pollen and House Dust Mite and Having Completed the Previous EPAAC Trial (NCT00152464)

NCT ID: NCT00160563

Last Updated: 2015-03-03

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

207 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-06-30

Study Completion Date

2006-03-31

Brief Summary

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Prolongation of the EPAAC™ trial - NCT00152464 (The Early Prevention of Asthma in Atopic Children).

36 months study to evaluate the efficacy and safety of levocetirizine (LCTZ) in preventing the onset of asthma in young atopic children.

Detailed Description

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Conditions

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Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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LCTZ-LCTZ

Levocetirizine after having been randomized to Levocetirizine in the preceding A00309 trial - NCT00152464 (LCTZ-LCTZ)

Group Type EXPERIMENTAL

LEVOCETIRIZINE

Intervention Type DRUG

5mg/mL oral drops, 0.125 mg/kg body weight, bid for 18 months

LCTZ-PLC

Placebo after having been randomized to Levocetirizine in the preceding A00309 trial - NCT00152464 (LCTZ - PLC)

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Oral drops, bid for 18 months

PLC-PLC

Placebo after having been randomized to Placebo in the preceding A00309 trial - NCT00152464 (PLC-PLC)

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Oral drops, bid for 18 months

Interventions

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LEVOCETIRIZINE

5mg/mL oral drops, 0.125 mg/kg body weight, bid for 18 months

Intervention Type DRUG

Placebo

Oral drops, bid for 18 months

Intervention Type OTHER

Other Intervention Names

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Xyzal®

Eligibility Criteria

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Inclusion Criteria

* Having completed the previous 18-month treatment period of the EPAAC trial - NCT00152464

Exclusion Criteria

* None
Minimum Eligible Age

30 Months

Maximum Eligible Age

42 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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UCB Pharma

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Isabelle Campine, MD

Role: STUDY_DIRECTOR

UCB Pharma

Locations

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North Adelaide, , Australia

Site Status

Parkville (North Melbourne), , Australia

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Brussels, , Belgium

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Brno, , Czechia

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Hradec Králové, , Czechia

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Olomouc, , Czechia

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Ostrava, , Czechia

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Plezen-Lochotin, , Czechia

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Prague, , Czechia

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Martigues, , France

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Saint-Etienne, , France

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Tarbes, , France

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Toulouse, , France

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Bayreuth, , Germany

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Berlin, , Germany

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Bielefeld, , Germany

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Bochum, , Germany

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Cologne, , Germany

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Erlangen, , Germany

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München, , Germany

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Wesel, , Germany

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Ancona, , Italy

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Bari, , Italy

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Bologna, , Italy

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Messina, , Italy

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Milan, , Italy

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Napoli, , Italy

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Pavia, , Italy

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Roma, , Italy

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Bialystock, , Poland

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Gdansk, , Poland

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Karpacz, , Poland

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Lodz, , Poland

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Lublin, , Poland

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Rabka-Zdrój, , Poland

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Warsaw, , Poland

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Wroclaw, , Poland

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Bellville, , South Africa

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Clarement, , South Africa

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Durban, , South Africa

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Mowbray, , South Africa

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Pietermaritzburg, , South Africa

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Sydenham, , South Africa

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West Honeydew, , South Africa

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Westville, , South Africa

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Wynberg, , South Africa

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Barcelona, , Spain

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Espluques de Llobreqat, , Spain

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Dorchester, , United Kingdom

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Enfield, , United Kingdom

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Southampton, , United Kingdom

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Countries

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Australia Belgium Czechia France Germany Italy Poland South Africa Spain United Kingdom

Related Links

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Other Identifiers

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A00384

Identifier Type: -

Identifier Source: org_study_id

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