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WT1 Peptid Vaccination in Carcinomas

NCT ID: NCT00153608

Last Updated: 2006-02-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-04-30

Brief Summary

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In this trial HLA-A2+ patients with WT1 expressing carcinomas are vaccinated with a peptide from the leukemia associated antigen WT1 together with immunological adjuvants KLH as T-helper protein and GM-CSF

Detailed Description

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Conditions

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WT1 Expressing Carcinoma

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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WT1 126-134 peptide

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Metastatic cancer, no standard treatment option
* Resected cancer with minimal residual disease, no standard treatment option
* WT-1 expression
* HLA-A2

Exclusion Criteria

* Concurrent chemotherapy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Charite University, Berlin, Germany

OTHER

Sponsor Role lead

Principal Investigators

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Ulrich Keilholz, MD

Role: PRINCIPAL_INVESTIGATOR

Charité CBF

Locations

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Hem&Onc Charité CBF

Berlin, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Carmen Scheibenbogen, MD

Role: CONTACT

[email protected]
+49-30-8445-4576

Facility Contacts

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Carmen Scheibenbogen, MD

Role: primary

[email protected]
+49-30-8445-4576

References

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Keilholz U, Menssen HD, Gaiger A, Menke A, Oji Y, Oka Y, Scheibenbogen C, Stauss H, Thiel E, Sugiyama H. Wilms' tumour gene 1 (WT1) in human neoplasia. Leukemia. 2005 Aug;19(8):1318-23. doi: 10.1038/sj.leu.2403817.

Reference Type BACKGROUND
PMID: 15920488 (View on PubMed)

Other Identifiers

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EU

Identifier Type: -

Identifier Source: secondary_id

HaemaCBFWT104

Identifier Type: -

Identifier Source: org_study_id