WelChol® With Metformin in Treating Patients With Type 2 Diabetes

NCT ID: NCT00147719

Last Updated: 2012-01-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-06-30

Study Completion Date

2006-07-31

Brief Summary

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The purpose of the study is to see how safe and effective and tolerable the use of colesevelam hydrochloride is for type 2 diabetes when added to metformin alone or in combination with other anti-diabetic drugs.

Detailed Description

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Conditions

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Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Colesevelam hydrochloride

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age 18-75 years, inclusive
* Diagnosed with type 2 diabetes
* Hemoglobin (HbA1c) between 7.5% to 9.5%
* Prescribed an ADA accepted diet
* Receiving stable dose of metformin alone or in combination with other oral anti-diabetic medications for 90 days before Visit 1

Exclusion Criteria

* History of type 1 diabetes or ketoacidosis
* History of chronic (more than 2 months) insulin therapy or the initiation of insulin for chronic treatment
* History of pancreatitis
* Uncontrolled hypertension
* Recent severe cardiovascular disease
* Allergy or toxic response to colesevelam or any of its components
* Body mass index (BMI) \>45 kg/m2
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Daiichi Sankyo

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CRO

Jonesboro, Arkansas, United States

Site Status

Beverly Hills, California, United States

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Carmichael, California, United States

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Fresno, California, United States

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Irvine, California, United States

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La Jolla, California, United States

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Los Gatos, California, United States

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San Diego, California, United States

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Spring Valley, California, United States

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West Hills, California, United States

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Washington D.C., District of Columbia, United States

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Coco Beach, Florida, United States

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Largo, Florida, United States

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Miami, Florida, United States

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Pembroke Pines, Florida, United States

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West Palm Beach, Florida, United States

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Atlanta, Georgia, United States

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Evansville, Indiana, United States

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Louisville, Kentucky, United States

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Detroit, Michigan, United States

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Troy, Michigan, United States

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Edina, Minnesota, United States

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Chesterfield, Missouri, United States

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Bozeman, Montana, United States

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Butte, Montana, United States

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Las Vegas, Nevada, United States

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Rochester, New York, United States

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Charlotte, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Lyndhurst, Ohio, United States

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Marion, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Tulsa, Oklahoma, United States

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Portland, Oregon, United States

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Beaver, Pennsylvania, United States

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Charleston, South Carolina, United States

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Columbia, South Carolina, United States

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Morristown, Tennessee, United States

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Corpus Christi, Texas, United States

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Dallas, Texas, United States

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Pharr, Texas, United States

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San Antonio, Texas, United States

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Arlington, Virginia, United States

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Richmond, Virginia, United States

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Mexico City, , Mexico

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Lima, , Peru

Site Status

Countries

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United States Mexico Peru

References

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Bays HE, Goldberg RB, Truitt KE, Jones MR. Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: glucose and lipid effects. Arch Intern Med. 2008 Oct 13;168(18):1975-83. doi: 10.1001/archinte.168.18.1975.

Reference Type DERIVED
PMID: 18852398 (View on PubMed)

Other Identifiers

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WEL-301

Identifier Type: -

Identifier Source: org_study_id

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