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Time Course of Procalcitonin and C Reactive Protein in Septic Patients Under Treatment With Corticosteroids

NCT ID: NCT00141973

Last Updated: 2008-05-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Study Classification

OBSERVATIONAL

Study Start Date

2004-11-30

Study Completion Date

2005-12-31

Brief Summary

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A systemic treatment with corticosteroids has been advocated for various bacterial infectious diseases. Since the production of CRP is down-regulated by corticosteroids, a smaller increase or a more rapid decrease of this acute phase protein will:

1. suggest attenuated systemic inflammation, but
2. does not necessarily reflect adequate therapy of the infection.

For several reasons (good diagnostic tool for sepsis, induction not decreased by immunosuppressive therapy), procalcitonin could be a better marker for activity of sepsis in patients under corticosteroids. As this issue has not yet been examined the investigators will prospectively study the time-course of PTC and CRP in a well-defined septic patient group, that in adjunction to antibiotic therapy also received systemic corticosteroid treatment and compare it to a similar group without corticosteroid treatment.

Detailed Description

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Conditions

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Sepsis

Keywords

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Procalcitonin Sepsis Corticosteroids

Study Design

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Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Acute exacerbation of chronic obstructive pulmonary disease (COPD) due to bacterial pneumonia

Exclusion Criteria

* Chronic systemic use of corticosteroids
Minimum Eligible Age

50 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Brahms SA, D-16761 Hennigsdorf bei Berlin

UNKNOWN

Sponsor Role collaborator

Ospedale Regionale Bellinzona e Valli

OTHER

Sponsor Role lead

Principal Investigators

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Andreas Perren, MD

Role: PRINCIPAL_INVESTIGATOR

Ospedale Regionale Bellinzona e Valli, CH-6500 Bellinzona

Locations

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Ospedale Regionale Bellinzona e Valli

Bellinzona, Canton Ticino, Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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CE1408

Identifier Type: -

Identifier Source: org_study_id