The Additional Value of Noninvasive Ventilation Next to Rehabilitation in Hypercapnic COPD Patients

NCT ID: NCT00135538

Last Updated: 2007-04-05

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE3
• Total Enrollment: 100 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2004-11-30
• Study Completion Date: 2009-04-30

Brief Summary

The purpose of this study is to investigate whether noninvasive ventilation by nose mask during the night has additional benefits next to pulmonary rehabilitation in patients with severe hypercapnic COPD.

Detailed Description

Several randomised controlled trials in patients with stable Chronic Obstructive Pulmonary Disease (COPD) have demonstrated that pulmonary rehabilitation (PR) improves dyspnoea, exercise tolerance, and health-related quality of life. Research in this field has been important in our department for several years. The first study in this respect was started in 1986 comparing outpatient rehabilitation with rehabilitation in the community in patients with severe COPD. This study showed that rehabilitation supervised by a physical therapist in the community is effective for a long period in contrast to outpatient rehabilitation. In 1990 the second study started showing that positive initial benefits of home based rehabilitation on quality of life can be maintained for 18 months if the patients visit the local physical therapist once a month.

However, less positive effects of rehabilitation have been reported in the more severe patients. Because of dyspnoea due to inspiratory muscle fatigue patients may not receive an adequate training stimulus, and therefore rehabilitation might be less effective. In these more severe patients alternative therapies are needed. These non-pharmacological treatments include nutritional supplementation, oxygen therapy, lung transplantation, lung volume reduction surgery and ventilatory support.

The last few years a discussion within the 4 home mechanical ventilation centres (HMV) in the Netherlands has been started about the role of chronic ventilatory support in end-stage COPD. Theoretically, it might be effective because:

1. a resetting of the respiratory centre may reduce daytime PaCO2;

2. a better internal milieu (pH, PaO2, PaCO2) may improve peripheral muscle function;

3. resting the respiratory muscles during the night may increase their daytime strength and endurance;

4. a reduction in the number of nocturnal arousals may improve the quality of sleep. Nevertheless, none of these mechanisms has been proven and currently there is no evidence that noninvasive positive pressure ventilation (NIPPV) should be given to stable patients with COPD. While several randomised controlled trials (RCT's) on NIPPV have been published with different outcomes, a recent meta-analysis did not show beneficial effects on blood gasses, lung function, respiratory muscle function and walking distance.

In contrast several uncontrolled studies did show clear benefits from NIPPV on gas-exchange, dyspnoea and quality of life. Possible reasons for these conflicting outcomes are differences in:

1. selection of patients,

2. adequacy of ventilatory support,

3. length of ventilatory support. Interestingly, it seems that studies with a positive outcome included mainly patients with hypercapnia, suggesting this as an important selection criterion.

The hypothesis is that long term NIPPV in hypercapnic patients with COPD may improve the effects of rehabilitation at home regarding health status, ADL function, dyspnoea and exercise tolerance. Secondly, we like to elucidate the exact mechanisms why NIPPV might be effective in this group of patients.

Comparison: patients who receive noninvasive ventilation during the night while following a pulmonary rehabilitation program with patients who only follow a rehabilitation program without receiving the noninvasive ventilation.

Conditions

Pulmonary Disease, Chronic Obstructive

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Interventions

Noninvasive positive pressure ventilation

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• COPD (FEV1< 50%, Tiffeneau < 70%)
• Dyspnoea on exertion and a reduced exercise capacity
• Age 75 years or less
• PaCO2 > 6.0 kPa at rest without oxygen

Exclusion Criteria

• Cardial/neuromuscular diseases limiting a successful rehabilitation
• Obstructive sleep apnoea syndrome: apnea/hypopnea index (AHI) > 10
• Previous exposure to chronic NIPPV
• Participation in a pulmonary rehabilitation program less than 18 months ago

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The Netherlands Asthma Foundation

OTHER

Sponsor Role: collaborator

Groningen Research Institute for Asthma and COPD

OTHER

Sponsor Role: lead

Principal Investigators

Marieke L Duiverman

Role: PRINCIPAL_INVESTIGATOR

University Medical Center Groningen

Locations

University medical Hospital Groningen

Groningen, Provincie Groningen, Netherlands

Countries

Netherlands

References

Altenburg WA, Duiverman ML, Ten Hacken NH, Kerstjens HA, de Greef MH, Wijkstra PJ, Wempe JB. Changes in the endurance shuttle walk test in COPD patients with chronic respiratory failure after pulmonary rehabilitation: the minimal important difference obtained with anchor- and distribution-based method. Respir Res. 2015 Feb 19;16(1):27. doi: 10.1186/s12931-015-0182-x.

Reference Type: DERIVED

PMID: 25849109 (View on PubMed)

Duiverman ML, Wempe JB, Bladder G, Vonk JM, Zijlstra JG, Kerstjens HA, Wijkstra PJ. Two-year home-based nocturnal noninvasive ventilation added to rehabilitation in chronic obstructive pulmonary disease patients: a randomized controlled trial. Respir Res. 2011 Aug 23;12(1):112. doi: 10.1186/1465-9921-12-112.

Reference Type: DERIVED

PMID: 21861914 (View on PubMed)

Duiverman ML, Wempe JB, Bladder G, Jansen DF, Kerstjens HA, Zijlstra JG, Wijkstra PJ. Nocturnal non-invasive ventilation in addition to rehabilitation in hypercapnic patients with COPD. Thorax. 2008 Dec;63(12):1052-7. doi: 10.1136/thx.2008.099044. Epub 2008 Aug 18.

Reference Type: DERIVED

PMID: 18710905 (View on PubMed)

Duiverman ML, Wempe JB, Bladder G, Kerstjens HA, Wijkstra PJ. Health-related quality of life in COPD patients with chronic respiratory failure. Eur Respir J. 2008 Aug;32(2):379-86. doi: 10.1183/09031936.00163607. Epub 2008 Apr 2.

Reference Type: DERIVED

PMID: 18385168 (View on PubMed)

Other Identifiers

RECOVER1

Identifier Type: -

Identifier Source: org_study_id