Docetaxel in Combination With GVAX ® Immunotherapy Versus Docetaxel and Prednisone in Prostate Cancer Patients

NCT ID: NCT00133224

Last Updated: 2008-09-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

408 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-07-31

Study Completion Date

2009-06-30

Brief Summary

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The primary objective of this study is to compare the duration of survival between patients receiving docetaxel in combination with the GVAX® vaccine for prostate cancer versus patients receiving docetaxel and prednisone treatment in patients with prostate cancer who no longer respond to hormone therapy, who have documented metastases with pain. Patients may have had up to one prior non-taxane chemotherapy treatment.

Detailed Description

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Conditions

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Prostate Cancer

Keywords

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Advanced Prostate Cancer HRPC Prostate Cancer Metastatic Hormone-refractory GVAX Chemotherapy Taxotere Docetaxel Prednisone Vaccine Allogeneic cells

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

Immunotherapy allogeneic GM-CSF secreting cellular vaccine

Intervention Type BIOLOGICAL

Immunotherapy allogeneic GM-CSF secreting cellular vaccine

2

Group Type OTHER

Chemotherapy (docetaxel and prednisone)

Intervention Type DRUG

Chemotherapy (docetaxel and prednisone)

Interventions

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Immunotherapy allogeneic GM-CSF secreting cellular vaccine

Immunotherapy allogeneic GM-CSF secreting cellular vaccine

Intervention Type BIOLOGICAL

Chemotherapy (docetaxel and prednisone)

Chemotherapy (docetaxel and prednisone)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Confirmed diagnosis of or clinical history consistent with adenocarcinoma of the prostate
* Metastatic prostate cancer deemed to be unresponsive or refractory to hormone therapy
* Detectable metastases
* ECOG performance status ≤2 (Performance status of 3 if due to bone pain)
* Any Gleason score
* Only one prior treatment with systemic chemotherapy
* No prior treatment with gene therapy
* No prior immunotherapy for prostate cancer
* Taxane naïve
* Experiencing cancer-related pain
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Cell Genesys

INDUSTRY

Sponsor Role lead

Responsible Party

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Cell Genesys, Inc.

Locations

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Alaska Clinical Research Center

Anchorage, Alaska, United States

Site Status

St. Edward Mercy Medical Center

Fort Smith, Arkansas, United States

Site Status

Loma Linda University

Loma Linda, California, United States

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Onocology Care Medical Associates

Los Angeles, California, United States

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Desert Hematology Oncology Medical Group

Rancho Mirage, California, United States

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San Bernardino Urology Associates

San Bernardino, California, United States

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Kaiser Permanente Medical Group Dept. of Oncology Research

San Diego, California, United States

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Sharp Healthcare

San Diego, California, United States

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California Pacific Medical Center

San Francisco, California, United States

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UCSF Mt. Zion Cancer Center

San Francisco, California, United States

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Cancer Research & Prevention Center

Soquel, California, United States

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Cancer Center and Department of Medicine

Aurora, Colorado, United States

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Mayo Clinic - Jacksonville

Jacksonville, Florida, United States

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Jupiter Hematology & Oncology Associates

Jupiter, Florida, United States

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Lakeland Regional Cancer Center

Lakeland, Florida, United States

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Hematology Oncology Associates of the Treasure Coast

Port Saint Lucie, Florida, United States

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Atlanta VA Medical Center

Atlanta, Georgia, United States

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Peachtree Hematology & Oncology Consultants, PC

Atlanta, Georgia, United States

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Emory Winship Cancer Institute

Atlanta, Georgia, United States

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Medical & Surgical Specialists

Galesburg, Illinois, United States

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James Graham Brown Cancer Center

Louisville, Kentucky, United States

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Frederick Memorial Hospital Regional Cancer Therapy Center

Frederick, Maryland, United States

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General Clinical Research Center University of Michigan

Ann Arbor, Michigan, United States

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Billings Clinic

Billings, Montana, United States

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Hematology & Oncology Consultants P.C.

Omaha, Nebraska, United States

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Nevada Cancer Institute

Las Vegas, Nevada, United States

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Hackensack University Medical Center

Hackensack, New Jersey, United States

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New Mexico Oncology

Albuquerque, New Mexico, United States

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North Shore Hematology Oncology Associates P.C.

East Setauket, New York, United States

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NYU Clinical Cancer Center

New York, New York, United States

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Presbyterian Hospital Center for Cancer Research

Charlotte, North Carolina, United States

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Gabrail Cancer Center

Canton, Ohio, United States

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Providence Portland Medical Center

Portland, Oregon, United States

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Kaiser Permanente Oncology/Hematology

Portland, Oregon, United States

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Cancer Centers of the Carolinas

Greenville, South Carolina, United States

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The West Clinic

Memphis, Tennessee, United States

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Center for Oncology Research & Treatment, PA

Dallas, Texas, United States

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Dallas Oncology Consultants

Dallas, Texas, United States

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Mary Crowley Medical Research Center

Dallas, Texas, United States

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Mobley Research Center

Houston, Texas, United States

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Northwest Cancer Center

Houston, Texas, United States

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Urology San Antonio Research, PA

San Antonio, Texas, United States

Site Status

Seattle Cancer Care Alliance, Univ. of Washington

Seattle, Washington, United States

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Ziekenhuis Netwerk Antwerpen - AZ Middelheim

Antwerp, , Belgium

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V.Z.W. Imelda Ziekenhuis

Bonheiden, , Belgium

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AZ Groeninge

Kortrijk, , Belgium

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CHU de Liège - Hôpital du Sart Tilman

Liège, , Belgium

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Heilig-Hartziekenhuis Campus Wilgenstraat

Roeselare, , Belgium

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Regionaal Ziekenhuis Sint Trudo

Sint-Truiden, , Belgium

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Centre Hospitalier de L'Universite de Montreal

Montreal, Quebec, Canada

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Centre Hospitalier Universite de Sherbrooke

Sherbrooke, Quebec, Canada

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Centre Regional de lutte contre le cancer Paul Papin

Angers, , France

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Centre Francois Baclesse

Caen, , France

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Institut Jean Godinot, Oncologie Medicale

Cedex, , France

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Centre Jean Perrin Centre Régional de lutte contre le cancer d'Auvergne

Clermont-Ferrand, , France

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Centre Rene Gauducheau - Site Hospitalier Nord

Nantes, , France

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Centre Antoine Lacassagne - Centre Regional de lutte contre le cancer

Nice, , France

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CHU Saint Louis

Paris, , France

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Hopital Saint Joseph Site Saint Michel

Paris, , France

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Hopital Cochin

Paris, , France

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CHU Poitiers

Poitiers, , France

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Centre Hospitalier Rene Dubos

Pontoise, , France

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Clinique Armoricaine de Radiology

Saint-Brieuc, , France

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Hopital Civil

Strasbourg, , France

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CHU Bretonneau

Tours, , France

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Centre Alexis Vautrin

Vandœuvre-lès-Nancy, , France

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Universitatsklinikum Aachen

Aachen, , Germany

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Charite Campus Mitte

Berlin, , Germany

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Krankenhaus Am Urban

Berlin, , Germany

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Universitatsklinikum Carl Gustav Carus An Der

Dresden, , Germany

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Klinikum der Johann Wolfgang Goethe-Universitat

Frankfurt am Main, , Germany

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Urologische Klinik und Poliklinik der Johannes Gutenberg Universitat Mainz

Mainz, , Germany

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Klinikum Mannheim

Mannheim, , Germany

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Urologische Klinik und Poliklinik

München, , Germany

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Fondazione IRCCS Ospedale Maggiore Policlinico

Milan, , Italy

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Fondazione San Raffaele del Monte Tabor

Milan, , Italy

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Istituto Europeo di Oncologia

Milan, , Italy

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Istituto Nazionale dei Tumori

Milan, , Italy

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Azienda Ospedaliero Universitaria di Modena

Modena, , Italy

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Azienda Ospedaliera Maggiore della Carita

Novarra, , Italy

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Azienda Ospedaliera di Parma

Parma, , Italy

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Azienda Ospedaliero Universitaria (A.O.U.) Pisana-Ospedale S. Chiara

Pisa, , Italy

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Azienda Ospedaliera San Camillo Forlanini

Roma, , Italy

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Presidio Ospedaliero di Sassari-Ospedale SS. Anunziata

Sassari, , Italy

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A.S.O. San Giovanni Battista di Torino

Turin, , Italy

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VU Medisch Centrum

Amsterdam, , Netherlands

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Academisch Centrum

Amsterdam, , Netherlands

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Universitair Medisch Centrum Groningen

Groningen, , Netherlands

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Samodzielny Publiczny Zaklad Opieki Zdrowotnej

Bialystok, , Poland

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Samodzielny Publiczny Zaklad Opieki Zdrowotnej

Bytom, , Poland

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Katedra i Klinika Onkologii i Radioterapli

Gdansk, , Poland

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Samodzielny Publiczny Zaklad Opieki Zdrowotnej

Katowice, , Poland

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Centrum Onkologii Instytut im. Marii Sklodowskiej-Curie Oddzial w Krakowie

Krakow, , Poland

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Wojewodzki Szpital Specjalistyczny im. M. Kopernika

Lodz, , Poland

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Samodzielny Publiczny Szpital Kliniczny nr 1 Przemienienia Panskiego AM w Poznaniu

Poznan, , Poland

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Wojewodzki Szpital Specjalistyczny w Siedlcach

Siedlce, , Poland

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Wojewodzki Szpital Specjalistyczny Oddzial Urologii

Słupsk, , Poland

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Szpital Kliniczny Dzieciatka Jezus - Centrum Leczenia Obrazen

Warsaw, , Poland

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Centrum Onkologii Instytut im. Marii Sklodowskiej- Curie

Warsaw, , Poland

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Universitetssjukhuset i Lund

Lund, , Sweden

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University Hospital MAS (UMAS)

Malmo, , Sweden

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Akademiska Sjukhuset i Uppsala

Uppsala, , Sweden

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Addenbrookes Hospital

Cambridge, , United Kingdom

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Royal Surrey County Hospital

Guildford, , United Kingdom

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St. James University Hospital

Leeds, , United Kingdom

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Lincoln County Hospital

Lincoln, , United Kingdom

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Royal Marsden Hospital

London, , United Kingdom

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Department of Oncology Hammersmith Hospital

London, , United Kingdom

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Christie Hospital Manchester

Manchester, , United Kingdom

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Clatterbridge Centre For Oncology

Metropolitan Borough of Wirral, , United Kingdom

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Mount Vernon Hospital

Middlesex, , United Kingdom

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Nottingham City Hospital

Nottingham, , United Kingdom

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Rosemere Cancer Centre, Royal Preston Hospital

Preston, , United Kingdom

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Scunthorpe General Hospital, Dept of Oncology

Scunthorpe, , United Kingdom

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Royal Marsden Academic Urology Unit

Sutton, , United Kingdom

Site Status

Countries

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United States Belgium Canada France Germany Italy Netherlands Poland Sweden United Kingdom

References

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Michael BD, Syndikus I, Clark A, Baborie A. Diffuse primary leptomeningeal melanocytosis in a patient receiving a novel cancer cell vaccine for prostate cancer. BMJ Case Rep. 2010 May 4;2010:bcr11.2009.2495. doi: 10.1136/bcr.11.2009.2495.

Reference Type DERIVED
PMID: 22736604 (View on PubMed)

Other Identifiers

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VITAL-2

Identifier Type: -

Identifier Source: secondary_id

G-0034

Identifier Type: -

Identifier Source: org_study_id