Adherence to Guidelines for Antibiotic Use in Respiratory Infections at Hospitals
NCT ID: NCT00129883
Last Updated: 2005-09-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
2000 participants
INTERVENTIONAL
2002-09-30
2005-04-30
Brief Summary
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Detailed Description
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To implement key recommendations in clinical practice, various strategies have been used, with mixed results. Perhaps the most important aspect of choosing a potentially effective intervention is that the choice of intervention should be based upon assessment of potential barriers in the target group. Many intervention studies are flawed by failing to control for secular trends.
The investigators performed a cluster randomised controlled trial, to study the effect of a multifaceted intervention strategy on the quality of antibiotic use for LRTI. Their intervention was tailored to the areas most in need for improvement and took perceived barriers in the target group into consideration at the individual hospital level.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
ECT
NONE
Interventions
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Professional education
Implementation of a Critical Care Pathway
Professional audit and feedback
Process analysis and redesign
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Patients with underlying immunodeficiency (HIV infection, neutropenia, treatment with immunomodulating drugs, active hematological malignancies, anatomical or functional asplenia and hypogammaglobulinemia)
* Patients already on treatment with antibiotics for another culture proven infection at the time of admission
* Patients from nursing homes
* Patients who had been transferred to another hospital or ICU and patients who had died within 24 hours of admission
* Patients with very poor prognosis (life expectancy \< 2 weeks on admission).
18 Years
ALL
No
Sponsors
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Radboud University Medical Center
OTHER
Principal Investigators
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Marlies E Hulscher, MSc, PhD
Role: PRINCIPAL_INVESTIGATOR
Centre for Quality of Care Research, Radboud University Nijmegen Medical Centre
Richard P Grol, MSc, PhD
Role: STUDY_DIRECTOR
Centre for Quality of Care Research, Radboud University Nijmegen Medical Centre
Jos WM van der Meer, MD, PhD
Role: STUDY_DIRECTOR
Department of General Internal Medicine, Radboud University Nijmegen Medical Centre
Locations
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Gelre Ziekenhuizen
Apeldoorn, , Netherlands
Deventer Ziekenhuis
Deventer, , Netherlands
Ziekenhuis Gelderse Vallei
Ede, , Netherlands
Bernhoven Ziekenhuis
Oss, , Netherlands
Bernhoven Ziekenhuis
Veghel, , Netherlands
Maxima Medisch Centrum
Veldhoven, , Netherlands
Vie Curi Medisch Centrum
Venlo, , Netherlands
Countries
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Related Links
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website of Centre for Quality of Care Research, department of the Radboud University Nijmegen Medical Centre, where this study was carried out
Other Identifiers
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ZonMw grant no. 2300.0024
Identifier Type: -
Identifier Source: secondary_id
AGAR-2001-1
Identifier Type: -
Identifier Source: org_study_id