Detection and Characterisation of Varicella Zoster Virus From Dermal Lesions of Chickenpox-infected Patients

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-06-07

Study Completion Date

2006-07-13

Brief Summary

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This study is conducted in order to collect clinical samples from patients who are diagnosed of having chickenpox infection. The results of this study will provide basic scientific information about chickenpox disease.

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Detailed Description

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The study involves NO therapeutic or prophylactic treatment nor further observation of the patients. There is no product to be tested in this study.

Conditions

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Varicella

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Varicella Group

Subjects aged between 0 and 16 years of age, with clinically-diagnosed primary varicella disease.

Group Type EXPERIMENTAL

Collection of clinical samples

Intervention Type PROCEDURE

The following samples were obtained from each subject:

* Vesicle fluid (VF) and vesicle swabs (VS) from four vesicles (for a total of eight samples)
* Papule swabs (PS) from four papules
* Crusts from two lesions
* One throat swab (TS) Up to 15 samples were to be obtained for each subject, when possible. VFs, VSs, PSs, and crusts were either stored dry or in liquid medium. TS samples were stored in liquid medium.

After extraction of DNA, samples were tested for the presence of varicella virus using a Quantitative Polymerase Chain Reaction (Q-PCR) technique.

Interventions

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Collection of clinical samples

The following samples were obtained from each subject:

* Vesicle fluid (VF) and vesicle swabs (VS) from four vesicles (for a total of eight samples)
* Papule swabs (PS) from four papules
* Crusts from two lesions
* One throat swab (TS) Up to 15 samples were to be obtained for each subject, when possible. VFs, VSs, PSs, and crusts were either stored dry or in liquid medium. TS samples were stored in liquid medium.

After extraction of DNA, samples were tested for the presence of varicella virus using a Quantitative Polymerase Chain Reaction (Q-PCR) technique.

Intervention Type PROCEDURE