Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
350 participants
OBSERVATIONAL
2005-05-31
2008-06-30
Brief Summary
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The pathophysiology of cardiac dysfunction following SAH has not yet been fully elucidated. Many reports (mainly case reports) have been published, but so far no study has investigated the frequency of these abnormalities in a prospective manner, have correlated the occurrence of the different cardiac abnormalities, and have assessed which clinical variables can predict cardiac dysfunction. And only a limited number of studies have related neurological outcome with cardiac dysfunction.
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Detailed Description
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Methods: For this purpose serial echocardiograms and ECGs will be obtained and cardiac enzymes will be measured in 200-400 patients admitted to hospital with SAH in the four participating centers. The clinical variables that will be studied to predict cardiac dysfunction are: medical history, the CT-scan score, circulatory parameters, blood samples, medication, surgical intervention (coiling or clipping), and the neurological condition (Glasgow Coma Scale). The echocardiograms, ECGs and cardiac enzymes will be studied to determine if they have independent prognostic value for the outcome in SAH patients.
Expected Results: As ECG changes and drops in blood pressure are known to occur frequently, the researchers expect to find that cardiac contractile dysfunction in patients with SAH occurs more frequently than is assumed now. Moreover, if cardiac abnormalities have neurological prognostic significance further studies are needed for early recognition and treatment of the cardiac abnormalities in SAH, a condition with a very poor prognosis.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Admitted within 72 hours of the bleed
Exclusion Criteria
* Patients or patients' family unwillingness to participate
10 Years
ALL
No
Sponsors
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Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
OTHER
UMC Utrecht
OTHER
University Medical Center Groningen
OTHER
Erasmus Medical Center
OTHER
Amsterdam UMC, location VUmc
OTHER
Principal Investigators
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Frans C Visser, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Amsterdam UMC, location VUmc
Ivo A van der Bilt, MD
Role: STUDY_DIRECTOR
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Gabriel J Rinkel, MD PhD
Role: PRINCIPAL_INVESTIGATOR
UMC Utrecht
Arthur A Wilde, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Locations
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Academic Medical Center
Amsterdam, North Holland, Netherlands
Academic Medical Center
Amsterdam, , Netherlands
University Medical Center Groningen
Groningen, , Netherlands
Erasmus Medical Center Rotterdam
Rotterdam, , Netherlands
Saint Elisabeth Hospital
Tilburg, , Netherlands
University Medical Center Utrecht
Utrecht, , Netherlands
Countries
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References
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van der Bilt IA, Hasan D, van den Brink RB, Cramer MJ, van der Jagt M, van Kooten F, Regtien JG, van den Berg MP, Groen RJ, Cate FJ, Kamp O, Gotte MJ, Horn J, Girbes AR, Vandertop WP, Algra A, Rinkel GJ, Wilde AA; SEASAH (Serial Echocardiography After Subarachnoid Hemorrhage) Investigators. Time course and risk factors for myocardial dysfunction after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2015 Jun;76(6):700-5; discussion 705-6. doi: 10.1227/NEU.0000000000000699.
Other Identifiers
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04-193
Identifier Type: -
Identifier Source: org_study_id
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