'SPRING'-Study: "Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists"

NCT ID: NCT00119925

Last Updated: 2008-10-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

5200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-10-31

Study Completion Date

2009-05-31

Brief Summary

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The purpose of this study is to compare two different strategies to implement the existing Guideline programme on Subfertility, as issued by the Dutch Society of Obstetrics and Gynaecology (NVOG). Therefore, an innovative patient-directed strategy will be compared to a control strategy and effectiveness, costs and feasibility of both strategies will be assessed.

Detailed Description

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The Dutch Society of Obstetrics and Gynaecology (NVOG) has developed a guideline programme on Subfertility, including 9 guidelines concerning diagnosis and treatment of subfertility and a national IVF protocol.

However, guidelines in general do not implement themselves; large gaps consists between best evidence (as described in the guidelines) and practice, resulting in a large variation between professionals.

Our study will compare an innovative patient-directed strategy with a (minimal intervention) control strategy, and effectiveness, costs and feasibility of both will be assessed. We eventually aim at the most cost-effective strategy to implement the existing subfertility guideline programme.

Please Note: In our protocol, we consider only 'couples' undergoing fertility treatment; therefore, we aim at gathering information from approximately 5200 records, of both male and female participants. When reporting eventually on their treatment, we will consider them only as couples, resulting in reported numbers of approximately 2600 participating couples.

Conditions

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Male Infertility Female Infertility Ovarian Hyperstimulation Syndrome Premature Ovarian Failure Endometriosis

Keywords

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infertility guideline health care implementation intervention gynecology

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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minimal intervention

professional audit and feedback on current practice

Group Type ACTIVE_COMPARATOR

professional audit and feedback (guideline adherence)

Intervention Type BEHAVIORAL

feedback on current practice according to quality indicators

maximal intervention

multi-faceted intervention consisting of professional and patient elements

Group Type ACTIVE_COMPARATOR

patient education

Intervention Type BEHAVIORAL

patient leaflets about national guideline contents

professional audit and feedback (guideline adherence)

Intervention Type BEHAVIORAL

feedback on current practice according to quality indicators

professional education (communication/shared decision making)

Intervention Type BEHAVIORAL

educational tools for professionals concerning communication and shared decision making

information tools

Intervention Type OTHER

tools and checklists to improve information provision

Interventions

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patient education

patient leaflets about national guideline contents

Intervention Type BEHAVIORAL

professional audit and feedback (guideline adherence)

feedback on current practice according to quality indicators

Intervention Type BEHAVIORAL

professional education (communication/shared decision making)

educational tools for professionals concerning communication and shared decision making

Intervention Type BEHAVIORAL

information tools

tools and checklists to improve information provision

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* each patient, male or female, visiting the OPD for a subfertility related problem or treatment
* each patient admitted to the hospital with complications of an infertility treatment

Exclusion Criteria

* patients receiving insemination with donor sperm
* patients receiving ICSI treatment
* patients who are non-Dutch speaking or understand too little Dutch to fill out the questionnaires
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ZonMw: The Netherlands Organisation for Health Research and Development

OTHER

Sponsor Role collaborator

Radboud University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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dept. of Obstetrics and Gynecology

Principal Investigators

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Rosella PMG Hermens, MSc, PhD

Role: PRINCIPAL_INVESTIGATOR

Centre for Quality of Care Research

Jan AM Kremer, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre

Didi D Braat, Prof. MD PhD

Role: STUDY_CHAIR

Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre

Richard PT Grol, Prof. PhD

Role: STUDY_CHAIR

Centre for Quality of Care Research

E Adang

Role: STUDY_DIRECTOR

Department of Medical Technology Assessment, Radboud University Nijmegen Medical Centre

J MM van Lith, MD, PhD

Role: STUDY_DIRECTOR

Dutch Society of Obstetrics and Gynecology

G Zielhuis, Prof PhD

Role: STUDY_DIRECTOR

Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre

Locations

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Jeroen Bosch Ziekenhuis

's-Hertogenbosch, , Netherlands

Site Status RECRUITING

Gelre Ziekenhuizen

Apeldoorn, , Netherlands

Site Status RECRUITING

Rijnstate Ziekenhuis

Arnhem, , Netherlands

Site Status RECRUITING

Maasziekenhuis Pantein

Boxmeer, , Netherlands

Site Status RECRUITING

ZBC stichting Geertgen

De Mortel, , Netherlands

Site Status RECRUITING

Slingeland Ziekenhuis

Doetinchem, , Netherlands

Site Status RECRUITING

Ziekenhuis Gelderse Vallei

Ede, , Netherlands

Site Status RECRUITING

Catharina Ziekenhuis

Eindhoven, , Netherlands

Site Status RECRUITING

st Antonius Ziekenhuis

Nieuwegein, , Netherlands

Site Status RECRUITING

Radboud University Nijmegen Medical Centre

Nijmegen, , Netherlands

Site Status RECRUITING

Canisius Wilhelmina Ziekenhuis

Nijmegen, , Netherlands

Site Status RECRUITING

Bernhoven Ziekenhuis

Oss, , Netherlands

Site Status RECRUITING

Rivierenland Ziekenhuis

Tiel, , Netherlands

Site Status RECRUITING

Bernhoven Ziekenhuis

Veghel, , Netherlands

Site Status RECRUITING

Maxima Medisch Centrum

Veldhoven, , Netherlands

Site Status RECRUITING

Streekziekenhuis Zevenaar

Zevenaar, , Netherlands

Site Status RECRUITING

Countries

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Netherlands

Central Contacts

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Selma M Mourad, MD

Role: CONTACT

Phone: +31-24-3610590

Email: [email protected]

Rosella PMG Hermens, MSc, PhD

Role: CONTACT

Phone: +31-24-3613129

Email: [email protected]

Facility Contacts

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Carl Hamilton, MD

Role: primary

Laurens j van Dam, MD

Role: primary

Alex P Schmoutziguer, MD

Role: primary

Ineke Minkhorst, MD

Role: primary

Henk Ruis, MD

Role: primary

Eveline Tepe, MD

Role: primary

Eduard Scheenjes, MD

Role: primary

Peter A van Dop, MD, PhD

Role: primary

Jules Schagen van Leeuwen, MD

Role: primary

Jan AM Kremer, MD, PhD

Role: primary

Anton Franssen, MD

Role: primary

Jos Vollebergh, MD

Role: primary

Guido Muijsers, MD

Role: primary

Mirjam van Rozendaal, MD

Role: primary

Ben W Mol, MD

Role: primary

Vincent Blom, MD

Role: primary

References

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Mourad SM, Hermens RP, Liefers J, Akkermans RP, Zielhuis GA, Adang E, Grol RP, Nelen WL, Kremer JA. A multi-faceted strategy to improve the use of national fertility guidelines; a cluster-randomized controlled trial. Hum Reprod. 2011 Apr;26(4):817-26. doi: 10.1093/humrep/deq299. Epub 2010 Dec 6.

Reference Type DERIVED
PMID: 21134950 (View on PubMed)

Related Links

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http://www.wokresearch.nl

website of the Centre for Quality of Care (WOK)

Other Identifiers

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ZonMw grant no. 945-14-116

Identifier Type: -

Identifier Source: secondary_id

SPRING 2005-01

Identifier Type: -

Identifier Source: org_study_id