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Sensory Examination and Pharmacological Modulation of Oral Hyperexcitability in Patients With Atypical Odontalgia and Matched Healthy Controls

NCT ID: NCT00115102

Last Updated: 2006-06-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-03-31

Study Completion Date

2005-10-31

Brief Summary

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This project examines experimental pain and chronic pain in the mouth, specifically the condition called atypical odontalgia (AO:atypical toothpain). In 16 patients with AO and 16 healthy persons, capsaicin (chili-pepper) is applied to the gingiva to cause pain. This pain is evaluated by the participants. In three sessions, 3 different medications are tested for effect on the pain. The medications are fentanyl, S-ketamine and placebo-treatment (saline). The aim is to know more about pain mechanisms in AO in order to develop an effective treatment.

Detailed Description

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Conditions

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Odontalgia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

DOUBLE

Interventions

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fentanyl

Intervention Type DRUG

S-ketamine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Atypical odontalgia

Exclusion Criteria

* BMI \> 30
* Heart conditions
* Lung disease
* Diseases of the liver or kidneys
* Hypertension, untreated
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Danish Pain Research Center

OTHER

Sponsor Role collaborator

University of Aarhus

OTHER

Sponsor Role lead

Principal Investigators

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Troels Staehelin Jensen, MD, PhD, Dr.Sci

Role: STUDY_CHAIR

Aarhus University Hospital

Locations

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Danish Pain Research Center

Aarhus, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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AO1

Identifier Type: -

Identifier Source: org_study_id