Safety Study of IPI-504 in Patients With Relapsed and Relapsed Refractory Multiple Myeloma

NCT ID: NCT00113204

Last Updated: 2008-05-20

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 18 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2005-06-30
• Study Completion Date: 2007-03-31

Brief Summary

This is a phase 1 clinical trial to find the safe, maximum tolerated dose of IPI-504 in patients with relapsed and/or relapsed, refractory multiple myeloma. This study will examine how IPI-504 is absorbed, distributed, metabolized, and eliminated by the body. The study will also evaluate potential anti-tumor activity of IPI-504.

Detailed Description

IPI-504 is a novel small molecule inhibitor of heat shock protein 90 (Hsp90), an emerging and recently identified target for cancer therapy. Hsp90 is a protein chaperone that plays a central role in regulating protein homeostasis. Hsp90 regulates the stability of key proteins (called "client proteins") and keeps them in the appropriate three dimensional shape so they can perform their cellular functions. In addition, many of the proteins stabilized by Hsp90 are oncoproteins and cell-signaling proteins important in cancer cell proliferation and cancer cell survival. Thus Hsp90, a single molecular target that is a central integrator of multiple pathways important to cancer, is an ideal novel target for oncologic therapy. Selective inhibition of Hsp90 will affect multiple downstream mechanisms to disrupt tumor growth and selectively kill cancer cells. The anti-neoplastic effects of Hsp90 inhibition have been demonstrated both in vitro and in vivo for a variety of different hematologic and solid tumors including multiple myeloma.

Conditions

Multiple Myeloma

Keywords

Multiple myeloma; Relapsed; Relapsed refractory; Hematologic cancer; hematologic disease; plasma cells

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Interventions

IPI-504

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Diagnosis of relapsed or relapsed, refractory disease
• Age is greater or equal to 18 years at the time of signing the informed consent
• Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
• Ability to adhere to the study visit schedule and all protocol requirements
• Voluntarily sign an informed consent
• All baseline studies must be completed for determining eligibility within 21 days of study enrollment
• Women of child-bearing potential (WCBP) defined as a sexually mature woman who has not undergone a hysterectomy or who has not been naturally post-menopausal for at least 24 consecutive months must have a negative serum or urine pregnancy test prior to each cycle of treatment
• All WCBP and all sexually active male patients must agree to use adequate methods of birth control throughout the study

Exclusion Criteria

• Disease specific treatment within the previous 3 weeks including use of chemotherapy that is known to be active or may be active against multiple myeloma
• Previous treatment with 17-AAG, DMAG, or other known Hsp90 inhibitor
• Participation in any investigational drug study within 3 weeks preceding start of treatment for conventional small molecule therapy or 4 weeks preceding the start of treatment for biologic or vaccine therapy; concurrent radiation therapy is not permitted
• Concomitant use of corticosteroids may not exceed prednisone 10 mg per day with the exception of pre-medication for transfusion of blood products and topical application
• Concurrent treatment with any agent that alters CYP3A activity (unless maintained on stable dose)
• Baseline QTc >450
• NYHA class 3 or 4 congestive heart failure
• Left Bundle Branch Block
• Mycardial infarction or active ischemic heart disease within 6 months
• Grade 3 or greater peripheral neuropathy
• Renal insufficiency, serum creatinine >2x upper limit of normal (ULN)
• Platelets < 30,000 mm3 or refractory to transfusion and unable to be maintained > 50,000 mm3
• AST and / or ALT > 2.0x ULN
• ANC <1,000 cells/mm3
• Hemoglobin < 8.0 g/dL
• Presence of active infection or systemic use of antibiotics within 72 hours of treatment
• WCBP who are breast feeding
• Significant co-morbid condition or disease which in the judgment of the investigator would place the patient at undue risk or interfere with the study (e.g. cardiac disease such as acute coronary syndrome or unstable angina within 6 months, New York Heart Association (NYHA) class 2 or greater congestive heart failure (CHF), uncontrolled hypertension, arrhythmia requiring medication or mechanical control, chronic obstructive pulmonary disease (COPD), cirrhotic liver disease, or other conditions)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Infinity Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role: lead

Principal Investigators

Sundar Jagannath, MD

Role: PRINCIPAL_INVESTIGATOR

St. Vincent's Comprehensive Cancer Center

David S. Siegel, MD; Ph.D

Role: PRINCIPAL_INVESTIGATOR

Hackensack Meridian Health

Ivan Borrello, MD

Role: PRINCIPAL_INVESTIGATOR

Johns Hopkins - Sidney Kimmel Comprehensive Cancer Center

Paul Richardson, MD

Role: PRINCIPAL_INVESTIGATOR

Dana-Farber Cancer Institute

Locations

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Baltimore, Maryland, United States

Dana-Farber Cancer Institute

Boston, Massachusetts, United States

Hackensack University Medical Center The David Jurist Research Center

Hackensack, New Jersey, United States

St. Vincent's Comprehensive Cancer Center

New York, New York, United States

Countries

United States

References

Maloney A, Workman P. HSP90 as a new therapeutic target for cancer therapy: the story unfolds. Expert Opin Biol Ther. 2002 Jan;2(1):3-24. doi: 10.1517/14712598.2.1.3.

Reference Type: BACKGROUND

PMID: 11772336 (View on PubMed)

Pratt WB, Toft DO. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp Biol Med (Maywood). 2003 Feb;228(2):111-33. doi: 10.1177/153537020322800201.

Reference Type: BACKGROUND

PMID: 12563018 (View on PubMed)

Neckers L. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med. 2002;8(4 Suppl):S55-61. doi: 10.1016/s1471-4914(02)02316-x.

Reference Type: BACKGROUND

PMID: 11927289 (View on PubMed)

Related Links

http://www.multiplemyeloma.org/

Click here for more information about Multiple Myeloma

Other Identifiers

IPI-504-01

Identifier Type: -

Identifier Source: org_study_id