Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
900 participants
OBSERVATIONAL
2000-12-31
2011-06-30
Brief Summary
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Detailed Description
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In this clinical study, investigators are studying groups of siblings in which at least two of the siblings have had an ischemic stroke. The goal of this multi-center study is to find the genes that increase the risk of developing an ischemic stroke.
To accomplish the aims of the study, researchers are using DNA samples collected from concordant (stroke-affected) sibling pairs to determine if there are regions in the human genome associated with ischemic stroke or that may harbor stroke susceptibility genes.
Two teaspoons of blood will be collected from each participant and submitted for genetic analysis. Understanding the genetic predisposition to stroke could have major benefits for public health.
Conditions
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Study Design
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FAMILY_BASED
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Head Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) done within 7 days of symptom onset confirms absence of etiology other than ischemic stroke.
* Subject reports having at least one living sibling with a stroke.
* Subject is 18 years of age or older.
Exclusion Criteria
* The index ischemic stroke occurred within 60 days after a non-traumatic subarachnoid hemorrhage.
* The subject has brain biopsy-proven central nervous system vasculitis.
* The subject is known to have any one of the following genetic disorders: CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), Fabry's disease, homocystinuria, MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, Stroke), or sickle cell anemia.
* The subject has a mechanical aortic valve or mechanical mitral valve.
* The subject had untreated or actively treated bacterial endocarditis at the time of the index ischemic stroke.
18 Years
ALL
No
Sponsors
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National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Mayo Clinic
OTHER
Responsible Party
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Mayo Clinic College of Medicine Jacksonville
Principal Investigators
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James F. Meschia, M.D.
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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University of South Alabama
Mobile, Alabama, United States
Mayo Clinic Arizona
Scottsdale, Arizona, United States
East Bay Region Assoc.
Berkeley, California, United States
Scripps Clinic
La Jolla, California, United States
University of California, Davis
Sacramento, California, United States
Mercy General Hospital
Sacramento, California, United States
Shands Jacksonville
Jacksonville, Florida, United States
Mayo Clinic College of Medicine Jacksonville
Jacksonville, Florida, United States
Florida Neurovascular Institute
Tampa, Florida, United States
Cleveland Clinic - Florida
Weston, Florida, United States
OSF St. Francis Medical Center
Peoria, Illinois, United States
Indiana University/Clarian Health Partners
Indianapolis, Indiana, United States
Mercy Medical Center
Sioux City, Iowa, United States
University of Maryland
Baltimore, Maryland, United States
Mayo Clinic
Rochester, Minnesota, United States
Washington University School of Medicine
St Louis, Missouri, United States
Rochester General Hospital
Rochester, New York, United States
Helen Hayes Hospital
West Haverstraw, New York, United States
Wake Forest University School of Medicine
Winston-Salem, North Carolina, United States
University of Cincinnati
Cincinnati, Ohio, United States
Metro Health
Cleveland, Ohio, United States
Ohio State University
Columbus, Ohio, United States
University of Penn. Med. Center
Philadelphia, Pennsylvania, United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
University of Virginia
Charlottesville, Virginia, United States
St. Mary's Medical Center
Huntington, West Virginia, United States
Luther Midelfort Clinic
Eau Claire, Wisconsin, United States
University of Wisconsin, Madison
Madison, Wisconsin, United States
Froedtert Memorial Lutheran
Milwaukee, Wisconsin, United States
Hospital Charles Le Moyne
Greenfield Park, Quebec, Canada
L'Enfant-Jesus Hospital
Québec, Quebec, Canada
Countries
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Other Identifiers
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1082-99
Identifier Type: -
Identifier Source: org_study_id