Childhood Autism Risks From Genetics and the Environment (The CHARGE Study)
NCT ID: NCT00106652
Last Updated: 2017-09-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
2000 participants
OBSERVATIONAL
2001-09-30
2017-09-30
Brief Summary
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Detailed Description
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This case-control study is the first large-scale epidemiologic investigation of underlying causes for autism and triggers of regression. This study capitalizes on the strengths of the case-control design, which is well suited to examine a broad array of factors for rare conditions that are thought to be multifactorial. Comparisons will be made with both general population controls and mentally retarded children.
The aims are to assess the influence of exogenous exposures, the role of susceptibility factors, and the interplay between these two in the etiology of autism and its phenotypic variation. Chemicals with known or suspected neurodevelopmental toxicity, such as PCB's, certain pesticides, and metals, are being investigated. This study pursues several hypotheses that have recently gained attention, including the combined measles, mumps, rubella vaccine and mercury present in vaccines given during infancy and early childhood. Additionally, biochemical susceptibility is examined through characterization of metabolic, immunologic, and neuronal gene expression profiles and genetic polymorphisms.
Conditions
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Study Design
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OTHER
Eligibility Criteria
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Inclusion Criteria
* Born in California
* Parents must speak either English or Spanish
* Children must be living with at least one biologic parent
Exclusion Criteria
* Children not residing in selected geographical areas (please contact for more information about specific study locations)
24 Months
60 Months
ALL
Yes
Sponsors
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University of California, Davis
OTHER
University of California, Los Angeles
OTHER
National Institute of Environmental Health Sciences (NIEHS)
NIH
Principal Investigators
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Isaac N. Pessah, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of California, Davis
Irva Hertz-Picciotto, Ph.D.
Role: STUDY_DIRECTOR
University of California, Davis
Locations
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University of California
Davis, California, United States
Countries
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Related Links
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click for more information about this study: Childhood Autism Risks from Genetics and the Environment
click here for more information about the UC Davis M.I.N.D. Institute
Other Identifiers
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200210574-4
Identifier Type: -
Identifier Source: secondary_id
11269-CP-001
Identifier Type: -
Identifier Source: org_study_id