Vinflunine in Patients With Locally Advanced or Metastatic Transitional Cell Carcinoma of the Urothelium

NCT ID: NCT00101608

Last Updated: 2010-03-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-01-31

Study Completion Date

2007-04-30

Brief Summary

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The purpose of this clinical research study is to learn if vinflunine can shrink or slow the growth of the cancer or increase survival in patients with transitional cell carcinoma of the urothelium. The safety of this treatment will also be studied.

Detailed Description

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Conditions

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Transitional Cell Carcinoma Bladder Neoplasms Kidney Neoplasms Ureter Neoplasms Bladder Cancer Neoplasm, Bladder

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

vinflunine

Intervention Type DRUG

solution for injection, IV, 280/320 mg/m2, every 3 wks, variable duration

Interventions

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vinflunine

solution for injection, IV, 280/320 mg/m2, every 3 wks, variable duration

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of transitional cell carcinoma of the urothelium that is locally advanced or metastatic (i.e. patients cannot be candidates for local/regional control of disease).
* Relapse or progression within 12.5 months of prior cisplatin or carboplatin containing chemotherapy regimen.
* Adequate performance status (Karnofsky greater or equal to 80).

Exclusion Criteria

* Receipt of more than 1 prior chemotherapy regimen in any setting.
* Prior discontinuation of platinum due solely to toxicity.
* Current neuropathy greater or equal to CTC grade 2.
* Prior radiation to greater or equal to 30% of bone marrow.
* Inadequate hematologic function: ANC \<1,500 cells/mm3, Platelet\<100,000 cells/mm3.
* Inadequate hepatic function: total bilirubin \> 1.5 times ULN, ALT/AST \> 2.5 times ULN or \> 5 times ULN in case of liver metastasis.
* Inadequate renal function: creatinine clearance \<20 ml/min.
* Prior allergy to any vinca-alkaloid.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pierre Fabre Medicament

INDUSTRY

Sponsor Role collaborator

Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Bristol-Myers Squibb

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Local Institution

Beverly Hills, California, United States

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La Jolla, California, United States

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Los Angeles, California, United States

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Santa Monica, California, United States

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Stanford, California, United States

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Vallejo, California, United States

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Aurora, Colorado, United States

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New Haven, Connecticut, United States

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Washington D.C., District of Columbia, United States

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Jacksonville, Florida, United States

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Miami, Florida, United States

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Atlanta, Georgia, United States

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Honolulu, Hawaii, United States

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Chicago, Illinois, United States

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Joliet, Illinois, United States

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Urbana, Illinois, United States

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Louisville, Kentucky, United States

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Baltimore, Maryland, United States

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Burlington, Massachusetts, United States

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Ann Arbor, Michigan, United States

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Detroit, Michigan, United States

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Kansas City, Missouri, United States

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St Louis, Missouri, United States

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Las Vegas, Nevada, United States

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Lebanon, New Hampshire, United States

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Buffalo, New York, United States

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New York, New York, United States

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The Bronx, New York, United States

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Charlotte, North Carolina, United States

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Durham, North Carolina, United States

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Cincinnati, Ohio, United States

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Philadelphia, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Providence, Rhode Island, United States

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Nashville, Tennessee, United States

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Dallas, Texas, United States

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Seattle, Washington, United States

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Milwaukee, Wisconsin, United States

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Liverpool, New South Wales, Australia

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Sydney, New South Wales, Australia

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Taree, New South Wales, Australia

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Waratah, New South Wales, Australia

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Westmead, New South Wales, Australia

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Adelaide, South Australia, Australia

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Linz, , Austria

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Salzburg, , Austria

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Edmonton, Alberta, Canada

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London, Ontario, Canada

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Toronto, Ontario, Canada

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Montreal, Quebec, Canada

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Caen, , France

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Le Mans, , France

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Nice, , France

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Paris, , France

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Toulouse, , France

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Nea Liosia, , Greece

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Jakarta, , Indonesia

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Genova, , Italy

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Milan, , Italy

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Roma, , Italy

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Rome, , Italy

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Viterbo, , Italy

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Cebu City, , Philippines

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Quezon, , Philippines

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Quezon City, , Philippines

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Singapore, , Singapore

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Seoul, , South Korea

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Murcia, , Spain

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Palma de Mallorca, , Spain

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Santander, , Spain

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Seville, , Spain

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Linköping, , Sweden

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Uppsala, , Sweden

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Aarau, , Switzerland

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Bangkok, , Thailand

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Countries

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United States Australia Austria Canada France Greece Indonesia Italy Philippines Singapore South Korea Spain Sweden Switzerland Thailand

Other Identifiers

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CA183-001

Identifier Type: -

Identifier Source: org_study_id

NCT00268424

Identifier Type: -

Identifier Source: nct_alias

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