A Study of An Approved Vaccine at Mumps Expiry Potency in Healthy Children 12 to 18 Months of Age (V205C-007)(COMPLETED)

NCT ID: NCT00092391

Last Updated: 2015-10-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1997 participants

Study Classification

INTERVENTIONAL

Study Start Date

1999-02-28

Study Completion Date

2001-07-31

Brief Summary

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The purpose of this study is to determine the mumps virus strength at the end of shelf-life (expiration date) of an approved vaccine.

Detailed Description

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Conditions

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Measles Mumps Rubella Varicella

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Control Group

M-M-R(TM) II at current release potency

Group Type ACTIVE_COMPARATOR

Comparator: M-M-R(TM) II, measles, mumps, and rubella virus vaccine live

Intervention Type BIOLOGICAL

0.5 mL subcutaneous injection of one of three sub-lots on Day 0

Comparator: VARIVAX(TM) Varicella Virus Vaccine Live (Oka-Merck)

Intervention Type BIOLOGICAL

0.5 mL subcutaneous injection on Day 0

Mumps Expiry Group 1

M-M-R(TM) II at intermediate expiry potency

Group Type EXPERIMENTAL

Comparator: M-M-R(TM) II, measles, mumps, and rubella virus vaccine live

Intervention Type BIOLOGICAL

0.5 mL subcutaneous injection of one of three sub-lots on Day 0

Comparator: VARIVAX(TM) Varicella Virus Vaccine Live (Oka-Merck)

Intervention Type BIOLOGICAL

0.5 mL subcutaneous injection on Day 0

Mumps Expiry Group 2

M-M-R(TM) II at expiry potency

Group Type EXPERIMENTAL

Comparator: M-M-R(TM) II, measles, mumps, and rubella virus vaccine live

Intervention Type BIOLOGICAL

0.5 mL subcutaneous injection of one of three sub-lots on Day 0

Comparator: VARIVAX(TM) Varicella Virus Vaccine Live (Oka-Merck)

Intervention Type BIOLOGICAL

0.5 mL subcutaneous injection on Day 0

Interventions

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Comparator: M-M-R(TM) II, measles, mumps, and rubella virus vaccine live

0.5 mL subcutaneous injection of one of three sub-lots on Day 0

Intervention Type BIOLOGICAL

Comparator: VARIVAX(TM) Varicella Virus Vaccine Live (Oka-Merck)

0.5 mL subcutaneous injection on Day 0

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Healthy children 12 to 18 months of age

Exclusion Criteria

* History or prior exposure to measles, mumps, rubella or varicella
* History of anaphylactoid reactions or hypersensitivity to any component of the vaccine, including gelatin and neomycin
Minimum Eligible Age

12 Months

Maximum Eligible Age

18 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Monitor

Role: STUDY_DIRECTOR

Merck Sharp & Dohme LLC

Other Identifiers

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2004_073

Identifier Type: -

Identifier Source: secondary_id

V205C-007

Identifier Type: -

Identifier Source: org_study_id

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