Pexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction (APEX-AMI)

NCT ID: NCT00091637

Last Updated: 2023-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

5745 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-04-30

Study Completion Date

2007-05-31

Brief Summary

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In the setting of reperfusion therapy in an acute myocardial infarction using primary percutaneous intervention (PCI), the body's own inflammatory system involving the complement cascade may be harmful. This study will test the safety and efficacy of a novel complement inhibitor, pexelizumab to reduce mortality at 30 days.

Detailed Description

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Conditions

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Acute Myocardial Infarction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

Placebo infusion

Group Type PLACEBO_COMPARATOR

Placebo infusion

Intervention Type DRUG

bolus infusion over a 10 minute period once

2

Pexelizumab infusion

Group Type EXPERIMENTAL

Pexelizumab

Intervention Type DRUG

Pexelizumab (2 mg/kg) intravenous , bolus for 10 minutes once

Interventions

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Pexelizumab

Pexelizumab (2 mg/kg) intravenous , bolus for 10 minutes once

Intervention Type DRUG

Placebo infusion

bolus infusion over a 10 minute period once

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Cardiac symptoms for at least 20 minutes within past 6 hours;
* Will undergo primary PCI;
* Has ECG evidence of acute high risk ST elevation myocardial infarction;
* Willing and able to be followed for at least 12 months.

Exclusion Criteria

* Isolated low risk inferior wall myocardial infarction;
* Received fibrinolytic therapy;
* History of complement deficiency;
* Suspected neisserial infection;
* Participating in other investigational study;
* Pregnancy;
* Previous enrollment.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Procter and Gamble

INDUSTRY

Sponsor Role lead

Responsible Party

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Procter and Gamble Pharmaceuticals

Principal Investigators

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Thomas G Todaro, MD, JD, FACC

Role: STUDY_DIRECTOR

Procter and Gamble

Locations

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Huntsville Hospital

Huntsville, Alabama, United States

Site Status

Mayo Clinic Hospital

Phoenix, Arizona, United States

Site Status

North Phoenix Heart Center

Phoenix, Arizona, United States

Site Status

Northwest Medical Center

Tucson, Arizona, United States

Site Status

Sparks Regional Medical Center

Fort Smith, Arkansas, United States

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Arkansas State Hospital

Little Rock, Arkansas, United States

Site Status

Brotman Medical Center

Beverly Hills, California, United States

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Providence Saint Joseph Medical Center

Burbank, California, United States

Site Status

Palomar Medical Center

Escondido, California, United States

Site Status

Los Angeles Community Hospital

Los Angeles, California, United States

Site Status

Memorial Medical Center

Modesto, California, United States

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Sutter Memorial Hospital

Sacramento, California, United States

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University of CA, San Diego Medical

San Diego, California, United States

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Sutter Medical Center of Santa Rosa

Santa Rosa, California, United States

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Providence Holy Cross Medical Center

Valencia, California, United States

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University of Colorado Hospital

Denver, Colorado, United States

Site Status

St. Vincent Medical Center

Bridgeport, Connecticut, United States

Site Status

University of Connecticut Health Center

Farmington, Connecticut, United States

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Yale - New Haven

New Haven, Connecticut, United States

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George Washington University Hospital

Washington D.C., District of Columbia, United States

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JFK Medical Center

Atlantis, Florida, United States

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Morton Plant Hospital

Clearwater, Florida, United States

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North Ridge Medical Center

Fort Lauderdale, Florida, United States

Site Status

St. Luke's Hospital

Jacksonville, Florida, United States

Site Status

Health First Holmes Regional Medical Center

Melbourne, Florida, United States

Site Status

Florida Heart Hospital

Orlando, Florida, United States

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Sarasota Memorial Hospital

Sarasota, Florida, United States

Site Status

University Community Hospital

Tampa, Florida, United States

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St. Luke's Regional Medical Center

Boise, Idaho, United States

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Highland Park Hospital

Bannockburn, Illinois, United States

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Ingalls Hospital

Harvey, Illinois, United States

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Advocate Good Samaritan

Lombard, Illinois, United States

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Elmhurst Hospital

Lombard, Illinois, United States

Site Status

Trinity Medical Center

Moline, Illinois, United States

Site Status

Saint Francis Medical Center

Peoria, Illinois, United States

Site Status

Trinity Medical Center

Rock Island, Illinois, United States

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Methodist Hospital

Indianapolis, Indiana, United States

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VAMC

Indianapolis, Indiana, United States

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Community Hospital South

Indianapolis, Indiana, United States

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The Indiana Heart Hospital

Indianapolis, Indiana, United States

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Munster Community Hospital

Munster, Indiana, United States

Site Status

Iowa Heart

Des Moines, Iowa, United States

Site Status

Via Christi Reginal Medical Center

Wichita, Kansas, United States

Site Status

Central Baptist Hospital

Lexington, Kentucky, United States

Site Status

University of Kentucky

Lexington, Kentucky, United States

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The Jewish Hospital

Louisville, Kentucky, United States

Site Status

Baptist Hospital East

Louisville, Kentucky, United States

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Lousiana Heart Center

Chalmette, Louisiana, United States

Site Status

Lousiana Heart Hospital

Lacombe, Louisiana, United States

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MCLNO at New Orleans University Campus

New Orleans, Louisiana, United States

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Tulane University Hospital and Clinic

New Orleans, Louisiana, United States

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Eastern Maine Medical Center

Bangor, Maine, United States

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Maine Medical Center

Portland, Maine, United States

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St. Joseph Medical Center

Towson, Maryland, United States

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Oakwood Hospital and Medical Center

Dearborn, Michigan, United States

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Henry Ford Hospital

Detroit, Michigan, United States

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Sinai-Grace Hospital

Detroit, Michigan, United States

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Spectrum Health

Grand Rapids, Michigan, United States

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Borgess Medical Center

Kalamazoo, Michigan, United States

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Mercy General Health Partners

Muskegon, Michigan, United States

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Northern Michigan Hospital

Petoskey, Michigan, United States

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St. Joseph Mercy-Oakland

Pontiac, Michigan, United States

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William Beaumont Hospital

Royal Oak, Michigan, United States

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Covenant Medical Center

Saginaw, Michigan, United States

Site Status

Saint Mary Medical Center

Saginaw, Michigan, United States

Site Status

Providence Hospital

Southfield, Michigan, United States

Site Status

William Beaumont Hospital

Troy, Michigan, United States

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Harper University Hospital

Warren, Michigan, United States

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Mercy Hospital

Coon Rapids, Minnesota, United States

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St. Mary's Duluth Clinic Health System

Duluth, Minnesota, United States

Site Status

Fairview Southdale Hospital

Edina, Minnesota, United States

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Abbott Northwestern Hospital

Minneapolis, Minnesota, United States

Site Status

North Memorial Medical Center

Minneapolis, Minnesota, United States

Site Status

Saint Mary Hospital

Rochester, Minnesota, United States

Site Status

St. Cloud Hospital

Saint Cloud, Minnesota, United States

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Methodist Hospital

Saint Louis Park, Minnesota, United States

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Health East St. Joseph Hospital

Saint Paul, Minnesota, United States

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University of Missouri Health Sciences Center

Columbia, Missouri, United States

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St. John's Hospital

Springfield, Missouri, United States

Site Status

St. Louis University Hospital

St Louis, Missouri, United States

Site Status

Barnes St. Peters Hospital

St Louis, Missouri, United States

Site Status

Deaconess Billings Clinic

Billings, Montana, United States

Site Status

St. Elizabeth Medical Center

Lincoln, Nebraska, United States

Site Status

Sunrise Hospital

Las Vegas, Nevada, United States

Site Status

Trinitas Hospital

Elizabeth, New Jersey, United States

Site Status

St. Joseph's Regional Medical Center

Fair Lawn, New Jersey, United States

Site Status

New Mexico Heart Institute

Albuquerque, New Mexico, United States

Site Status

Albany Medical Center

Albany, New York, United States

Site Status

Maimonides Medical Center

Brooklyn, New York, United States

Site Status

Wilson Memorial Medical Center

Johnson City, New York, United States

Site Status

Winthrop University Hospital

Mineola, New York, United States

Site Status

St. Vincent's Catholic Medical Center

New York, New York, United States

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Bellevue Hospital Center

New York, New York, United States

Site Status

Vassar Brothers Medical Center

Poughkeepsie, New York, United States

Site Status

Rochester General Hospital

Rochester, New York, United States

Site Status

SUNY - Upstate Medical University

Syracuse, New York, United States

Site Status

Monteflore Medical Center

The Bronx, New York, United States

Site Status

Presbyterian Hospital

Charlotte, North Carolina, United States

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Duke University Health Systems

Durham, North Carolina, United States

Site Status

Moses Cone Hospital/LeBauer Healthcare

Greensboro, North Carolina, United States

Site Status

Pitt County Memorial Hospital

Greenville, North Carolina, United States

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High Point Regional Health System

High Point, North Carolina, United States

Site Status

Trinity Hospital

Minot, North Dakota, United States

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Akron General Medical Center

Akron, Ohio, United States

Site Status

VAMC Cincinnati

Cincinnati, Ohio, United States

Site Status

Bethesda North Hospital

Cincinnati, Ohio, United States

Site Status

The University Hospital

Cincinnati, Ohio, United States

Site Status

University Hospitals of Cleveland

Cleveland, Ohio, United States

Site Status

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Site Status

MidWest Cardiology Research Foundation

Columbus, Ohio, United States

Site Status

Med Central Mansfield

Mansfield, Ohio, United States

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Genesis Healthcare System

Zanesville, Ohio, United States

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Midwest Regional Medical Center

Midwest City, Oklahoma, United States

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University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Site Status

VA Medical Center

Oklahoma City, Oklahoma, United States

Site Status

Integris Baptist Medical Center, Inc.

Oklahoma City, Oklahoma, United States

Site Status

Oklahoma Heart Hospital

Oklahoma City, Oklahoma, United States

Site Status

St. Charles Medical Center

Bend, Oregon, United States

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Providence Portland Medical Center

Portland, Oregon, United States

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Lehigh Valley Hospital

Allentown, Pennsylvania, United States

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Geisinger Medical Center

Danville, Pennsylvania, United States

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Genesis Medical Center

Davenport, Pennsylvania, United States

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Hamot Medical Center

Erie, Pennsylvania, United States

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Penn State Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

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Lancaster General Hospital

Lancaster, Pennsylvania, United States

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Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

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Temple University Hospital

Philadelphia, Pennsylvania, United States

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Jefferson Regional Medical Center

Pittsburgh, Pennsylvania, United States

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Allegheny General Hospital

Pittsburgh, Pennsylvania, United States

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Western Pennsylvania Hospital

Pittsburgh, Pennsylvania, United States

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VA Pittsburgh Healthcare System

Pittsburgh, Pennsylvania, United States

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The Chester County Hospital

West Chester, Pennsylvania, United States

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York Hospital

York, Pennsylvania, United States

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Rhode Island Hospital

Providence, Rhode Island, United States

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Palmetto Richland Memorial Hospital

Columbia, South Carolina, United States

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Sisters of Charity Providence Hospitals

Columbia, South Carolina, United States

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Rapid City Regional Hospital

Rapid City, South Dakota, United States

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Heart Hospital of South Dakota

Sioux Falls, South Dakota, United States

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Jackson-Madison County General Hospital

Jackson, Tennessee, United States

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Wellmont Holston Valley Medical Center

Kingsport, Tennessee, United States

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Fort Sanders Rgional Medical Center

Knoxville, Tennessee, United States

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Baptist Hospital of East Tennessee

Knoxville, Tennessee, United States

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Centennial Medical Center

Nashville, Tennessee, United States

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Methodist Medical Center

Oak Ridge, Tennessee, United States

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Northwest Texas Healthcare System

Amarillo, Texas, United States

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Seton Medical Center

Austin, Texas, United States

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Presbyterian Hospital of Dallas

Dallas, Texas, United States

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Medical City Dallas

Dallas, Texas, United States

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Dallas Medical Center

Dallas, Texas, United States

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Parkland Health & Hospital System

Dallas, Texas, United States

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Brooke Army Medical Center

Fort Sam Houston, Texas, United States

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Ben Taub General Hospital

Houston, Texas, United States

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Memorial Hermann Hospital

Houston, Texas, United States

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Michael E. DeBakey VA Medical Center

Houston, Texas, United States

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Houston Northwest Medical Center

Houston, Texas, United States

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Covenant Medical Center

Lubbock, Texas, United States

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Northeast Baptist Hospital

San Antonio, Texas, United States

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South Texas Veterans Health Care System Audie L. Murphy Division

San Antonio, Texas, United States

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Scott & White Memorial Hospital

Temple, Texas, United States

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East Texas Medical Center

Tyler, Texas, United States

Site Status

Trinity Mother Frances Hospital

Tyler, Texas, United States

Site Status

Citizens Medical Center

Victoria, Texas, United States

Site Status

Detar Hospital

Victoria, Texas, United States

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Cottonwood Hospital

Murray, Utah, United States

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Inova Alexandria Hospital

Alexandria, Virginia, United States

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Universitiy of Virginia Health Science Center

Charlottesville, Virginia, United States

Site Status

Rockingham Memorial Hospital

Harrisonburg, Virginia, United States

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Lynchburg General Hospital

Lynchburg, Virginia, United States

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Herrico Doctors' Hospital - Forest

Richmond, Virginia, United States

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Sentara Virginia Beach General Hospital

Virginia Beach, Virginia, United States

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Winchester Medical Center

Winchester, Virginia, United States

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Overtake Hospital Medical Center

Bellevue, Washington, United States

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Skagit Valley Hospital

Mount Vernon, Washington, United States

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Harborview Medical Center

Seattle, Washington, United States

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MultiCare Medical Center (Tacoma General Hospital)

Tacoma, Washington, United States

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St. Joseph Medical Center

Tacoma, Washington, United States

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West Virginia University Hospital

Morgantown, West Virginia, United States

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Franciscan Skemp Healthcare

La Crosse, Wisconsin, United States

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Froedtert Hospital

Milwaukee, Wisconsin, United States

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Waukesha Memorial Hospital

Waukesha, Wisconsin, United States

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Canberra Hospital

Garran, Australian Capital Territory, Australia

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Concord Hospital

Concord, New South Wales, Australia

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Gosford Hospital

Gosford, New South Wales, Australia

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St. George Hospital

Kogarah, New South Wales, Australia

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Liverpool Hospital

Liverpool, New South Wales, Australia

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Prince of Wales Hospital

Randwick, New South Wales, Australia

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Royal North Shore Hospital

St Leonards, New South Wales, Australia

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Prince Charles Hospital

Chermside, Queensland, Australia

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Townsville Hospital

Douglas, Queensland, Australia

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Princess Alexandra Hospital

Wooloong Abba, Queensland, Australia

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Royal Adelaide Hospital

Adelaide, South Australia, Australia

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Flinders Medical Centre

Bedford Park, South Australia, Australia

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The Queen Elizabeth Hospital

Woodville South, South Australia, Australia

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Austin Hospital

Box Hill, Victoria, Australia

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Box Hill Hospital

Box Hill, Victoria, Australia

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Monash Medical Centre

Clayton, Victoria, Australia

Site Status

Royal Melbourne Hospital

Parkville, Victoria, Australia

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Victorian Heart Clinic

Richmond, Victoria, Australia

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Fremantle Hospital

Fremantle, Western Australia, Australia

Site Status

Sir Charles Gairdner Hospital

Nedlands, Western Australia, Australia

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Royal Perth Hospital

Perth, Western Australia, Australia

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Krankenhaus der Barmherzigen Schwestern

Linz, , Austria

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Univ. Klinik f. Innere Medizin II

Vienna, , Austria

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Wilhelminenspital

Vienna, , Austria

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U.Z. Gasthuisberg

Leuven, Brabant, Belgium

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Helig Hartziekenhuis

Roeselare, Flanders, Belgium

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ZOL Campus Sint-Jan

Genk, Limburg, Belgium

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AZ Middelheim

Antwerp, , Belgium

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CHR de la Citadelle

Liège, , Belgium

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Foothills Medical Centre

Calgary, Alberta, Canada

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University of Alberta Hospital

Edmonton, Alberta, Canada

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Vancouver General Hospital

Vancouver, British Columbia, Canada

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St. Paul's Hospital

Vancouver, British Columbia, Canada

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Royal Jubilee Hospital

Victoria, British Columbia, Canada

Site Status

Saint John Regional Hospital - New Brunswick Heart Centre

Saint John, New Brunswick, Canada

Site Status

General Hospital Health Sciences Centre

St. John's, Newfoundland and Labrador, Canada

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Hamilton General Hospital

Hamilton, Ontario, Canada

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Trillium Health Center

Mississauga, Ontario, Canada

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Sunnybrook & Women's Health Sciences Centre

Toronto, Ontario, Canada

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Montreal Heart Institute/Research Centre

Montreal, Quebec, Canada

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Centre Hospitale de'Universite de Montreal (Pav Notre-Dame)_

Montreal, Quebec, Canada

Site Status

Hopital Sacre-Coeur de Montreal

Montreal, Quebec, Canada

Site Status

Quebec Heart Institute/Laval Hospital

Sainte-Foy, Quebec, Canada

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Centre Hospitalier Universitaire de Sherbrooke

Sherbrooke, Quebec, Canada

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Regina General Hospital

Regina, Saskatchewan, Canada

Site Status

Kardiologicke odd. Nemocnice Ceske Budejovice as

Caske Budejovice, Ceske Budejovice, Czechia

Site Status

I. Interni klinika, Fakultni nemocnice Hradec

Kradec Kralove, Hradec Kralove, Czechia

Site Status

Klinika kardiologie, IKEM

Prague, Prague, Czechia

Site Status

Kardiologicke oddeleni, Masarykova nemocnice

Labem, Usti Nad Labem, Czechia

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Interni kardiologicka klinika, Fakultni nemocnice Brno

Brno, , Czechia

Site Status

I. interni kardioangiologicka klinika, Fakultni nemocnice u Sv. Anny

Brno, , Czechia

Site Status

Kardiologicke odd., Krajska neocnice Liberec

Liberec, , Czechia

Site Status

I. Interni klinika, FN Olomouc

Olomouc, , Czechia

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Interni klinika, FNsP Ostrava

Ostrava, , Czechia

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Kardio-Troll sro and Krajska nemocnice Pardubice

Pardubice, , Czechia

Site Status

Kardio-Troll sro and Krajska nemocnice Pardubice

Pardubice, , Czechia

Site Status

I. Interni klinika, Fakultni nemocnice Plzen

Pilsen, , Czechia

Site Status

Kardiocentrum, Fakultni nemocnice Kralovske Vinohrady

Prague, , Czechia

Site Status

II. Interni klinika, Vseobecna fakultni nemocnice

Prague, , Czechia

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Kardiologicke odd., Nemocnice Na Homoice

Prague, , Czechia

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Kardiologicka klinika FN v Motole

Prague, , Czechia

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Kardiocentrum, Nemocnice Podlesi sro

Třinec, , Czechia

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Interni klinika, Batova nemocnice

Zlín, , Czechia

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Aalborg Sygehus

Aalborg, Danmark, Denmark

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Skejby Sygehus

Aarhus, Danmark, Denmark

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Rigshospitalet

Copenhagen, Danmark, Denmark

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Amtssygehuset i Gentofte

Hellerup, Danmark, Denmark

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Odense Universitets Hospital

Odense, , Denmark

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CHRU de Angers

Angers, , France

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Clinique Saint Joseph

Colmar, , France

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Cardiologie Hopital Simone Veil

Eaubonne-Montmorency, , France

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Centre Hospitalier de Haguenau

Haguenau, , France

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CHRU de Nantes

Nantes, , France

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Hopital Lariboisiere

Paris, , France

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Hopital Bichat

Paris, , France

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Hopital a Pitie Salpetriere

Paris, , France

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Hopital du Haut Leveque

Pessac, , France

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Hopital Pontchaillou

Rennes, , France

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CHRU de Rouen

Rouen, , France

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Centre Cardiologique du Nord

Saint-Denis, , France

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CHRU Hautepierre

Strasbourg, , France

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Hopital Rangueil

Toulouse, , France

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Hopital d'adultes de Brabois (CHU de Nancy)

Vandœuvre-lès-Nancy, , France

Site Status

Universitatsklinikum Mannheim

Mannheim, Baden-Wurttemberg, Germany

Site Status

Klinikum Augsburg, Stenglinstr. 2.

Augsburg, Bavaria, Germany

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Klinikum Coburg

Coburg, Bavaria, Germany

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Stadt Krankenhaus Muenchen-Bogenhausen

München, Bavaria, Germany

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Kerckhoff-Klinik Bad Anuheim

Bad Nauheim, Hesse, Germany

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Stadt. Kliniken Kassel

Kassel, Hesse, Germany

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Allgemeines Krankenhaus Celle

Celle, Lower Saxony, Germany

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Herzzentrum Gottingen

Göttingen, Lower Saxony, Germany

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St. Johannes Krankenhaus

Dortmund, Nordhein Westfalen, Germany

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Herzzentrum Duisburg

Duisburg, Nordhein Westfalen, Germany

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Kliniken der Stadt Koln

Cologne, North Rhine-Westphalia, Germany

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Klinikkum Lippe

Detmold, North Rhine-Westphalia, Germany

Site Status

Helios Klinikum Wuppertal GmbH

Wuppertal, North Rhine-Westphalia, Germany

Site Status

Klinikkum Ludwigshafen

Ludwigshafen am Rhein, Rhineland-Palatinate, Germany

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Herzzentrum

Bad Segeberg, Schleswig-Holstein, Germany

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Universitatsklinik Lubeck

Lübeck, Schleswig-Holstein, Germany

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Klinik fur Innere Medizin 1

Jena, Thuringia, Germany

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Herz-Zentrum Bad Krozingen

Krozingen, Wurrtemberg, Germany

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Universitatsklinik der Ruhr-Universitat Bochum

Bad Oeynhausen, , Germany

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Vivantes Klinikkum im Friedrichshain

Berlin, , Germany

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Vivantes Klinikum am Urban

Berlin, , Germany

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Allgemeines Krankenhaus St. Georg

Hamburg, , Germany

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Universitatsklinikum Hamburg-Eppendorf

Hamburg, , Germany

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Centro E Malan

San Donato Milanese, Milano, Italy

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Presidio Ospedaliero di Cittadella

Cittadella, Padova, Italy

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U.O. Cardiologia

Reggio Emilia, Reggio Emilla, Italy

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Osepdale degli Intermi

Rimni, Rimni, Italy

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A.O. SS. Antonio e Biagio e Cesare Arrigo

Alessandria, , Italy

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Policlinico Sant'Orsola-Malpighi

Bologna, , Italy

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Ospedale Centrale di Bolzano

Bolzano, , Italy

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A.O. Spedali di Civili

Brescia, , Italy

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A.O. della Regione Lombardia Presidio Ospedaliero Sant'Anna

Como, , Italy

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Ospedale Alessandro Manzoni

Lecco, , Italy

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Azienda Ospedaliera Carlo Poma

Mantova, , Italy

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Azienda Ospedaliera di Parma - Ospedale Maggiore

Parma, , Italy

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Policlinico San Matteo - I.R.C.C.S.

Pavia, , Italy

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A. O. S. Salvatore

Pesaro, , Italy

Site Status

AO S. Camillo Forlanini

Roma, , Italy

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Cardiologia Universitaria

Torino, , Italy

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Ospedale S. Maria di Ca'Foncello

Treviso, , Italy

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Catharina Hospital

Eindhovenb, BR, Netherlands

Site Status

Academic Hospital Maastricht

Maastricht, LI, Netherlands

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Medeisch Centrum Alkmaar

Alkmaar, North Holland, Netherlands

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VUMC

Amsterdam, North Holland, Netherlands

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OLVG

Amsterdam, North Holland, Netherlands

Site Status

Isla Klinieken Location De Weezenlanden

Zwolle, Overijssel, Netherlands

Site Status

Erasmus Medical Centre

Rotterdam, South Holland, Netherlands

Site Status

Medisch Centrum Rijnmond-Zuid

Rotterdam, South Holland, Netherlands

Site Status

Sint Antonius Hospital

Nieuwegein, Utrecht, Netherlands

Site Status

University Medical Center Utrecht

Ultrecht, Utrecht, Netherlands

Site Status

Christchurch Hospital

Christchurch, Canterbury, New Zealand

Site Status

Dunedin Hospital

Dunedin, Otago, New Zealand

Site Status

Waikato Hospital

Hamilton, Waikoto, New Zealand

Site Status

Auckland City Hospital

Auckland, , New Zealand

Site Status

Wellington Hospital

Wellington, , New Zealand

Site Status

I Klinika Kardiologii

Katowice - Ochojec, , Poland

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Klinika Chorob Serca i Naczyn

Krakow, , Poland

Site Status

II Katedra i Klinika Kardiologii

Lodz, , Poland

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I Klinika Choroby Wiencowej

Warsaw, , Poland

Site Status

SPZOZ Dolnoslaski Szpital Specjalistyczny

Wroclaw, , Poland

Site Status

Hospital Garcia de Orta - Servico de Cardiologia

Almada, Lisbon District, Portugal

Site Status

Hospital Santa Cruz

Carnaxide, Lisbon District, Portugal

Site Status

H. Fernando da Fonesca

Amadora, , Portugal

Site Status

Hospitals da Universidade de Coimbra

Coimbra, , Portugal

Site Status

Hospital Curry Cabral

Lisbon, , Portugal

Site Status

H. Santa Maria

Lisbon, , Portugal

Site Status

Hospital Sao Joao - Servico de Cardiologia

Porto, , Portugal

Site Status

Centro Hospitalar de Vila Nova de Gala

Vila Nova de Gala, , Portugal

Site Status

Ciutat Sanitaria i Universitaria de Bellvitge

L'Hospitalet de Llobregat, Barcelona, Spain

Site Status

Hospital Virgen da la Arrixaca

El Palmar, Murcia, Spain

Site Status

Hospital de Navarra

Pamplona, Navarre, Spain

Site Status

Hospital General Universitario de Alicante

Alicante, , Spain

Site Status

Hospital Clinic i Provincial

Barcelona, , Spain

Site Status

Hospital de Leon

León, , Spain

Site Status

Hospital General Universitario Gregorio Maranon

Madrid, , Spain

Site Status

Hospital Puerta de Hierro

Madrid, , Spain

Site Status

Hospital Clinico San Carlos

Madrid, , Spain

Site Status

Hospital Clinico Universitario Virgen de la Victoria

Málaga, , Spain

Site Status

Hopspital Virgen del Rocio

Seville, , Spain

Site Status

Universitetetssjukhuset Umea

Umeå, , Sweden

Site Status

Uppsala University Hospital

Uppsala, , Sweden

Site Status

Kantonsspital Basel

Bassel, Bassel, Switzerland

Site Status

University Hospital of Geneva

Geneva, Canton of Geneva, Switzerland

Site Status

Kantonsspital St. Gallen

Sankt Gallen, Canton of St. Gallen, Switzerland

Site Status

Cardiocentro Ticino

Lugano, Canton Ticino, Switzerland

Site Status

Herzklinik Bodensee am Weinberg AG

Kreuzlingen, Thurgau, Switzerland

Site Status

Countries

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United States Australia Austria Belgium Canada Czechia Denmark France Germany Italy Netherlands New Zealand Poland Portugal Spain Sweden Switzerland

References

Explore related publications, articles, or registry entries linked to this study.

Bagai A, Armstrong PW, Stebbins A, Mahaffey KW, Hochman JS, Weaver WD, Patel MR, Granger CB, Lopes RD. Prognostic implications of left ventricular end-diastolic pressure during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: Findings from the Assessment of Pexelizumab in Acute Myocardial Infarction study. Am Heart J. 2013 Nov;166(5):913-9. doi: 10.1016/j.ahj.2013.08.006. Epub 2013 Sep 24.

Reference Type DERIVED
PMID: 24176448 (View on PubMed)

Guptill JT, Mehta RH, Armstrong PW, Horton J, Laskowitz D, James S, Granger CB, Lopes RD. Stroke after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction: timing, characteristics, and clinical outcomes. Circ Cardiovasc Interv. 2013 Apr;6(2):176-83. doi: 10.1161/CIRCINTERVENTIONS.112.000159. Epub 2013 Apr 2.

Reference Type DERIVED
PMID: 23549644 (View on PubMed)

Westerhout CM, Pieper KS, James SK, Mahaffey KW, de Werf FV, Califf RM, Granger CB, Armstrong PW. Dynamic modeling of 90-day mortality in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Am Heart J. 2013 Mar;165(3):354-62.e2. doi: 10.1016/j.ahj.2012.12.001. Epub 2013 Jan 15.

Reference Type DERIVED
PMID: 23453104 (View on PubMed)

Patel MR, Westerhout CM, Granger CB, Brener SJ, Fu Y, Siha H, Kim RJ, Armstrong PW. Aborted myocardial infarction after primary percutaneous coronary intervention: magnetic resonance imaging insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Am Heart J. 2013 Feb;165(2):226-33. doi: 10.1016/j.ahj.2012.10.028. Epub 2012 Nov 24.

Reference Type DERIVED
PMID: 23351826 (View on PubMed)

Truffa AA, Granger CB, White KR, Newby LK, Mehta RH, Hochman JS, Patel MR, Pieper KS, Al-Khalidi HR, Armstrong PW, Lopes RD. Serious infection after acute myocardial infarction: incidence, clinical features, and outcomes. JACC Cardiovasc Interv. 2012 Jul;5(7):769-76. doi: 10.1016/j.jcin.2012.03.018.

Reference Type DERIVED
PMID: 22814783 (View on PubMed)

Martel C, Granger CB, Ghitescu M, Stebbins A, Fortier A, Armstrong PW, Bonnefoy A, Theroux P. Pexelizumab fails to inhibit assembly of the terminal complement complex in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Insight from a substudy of the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Am Heart J. 2012 Jul;164(1):43-51. doi: 10.1016/j.ahj.2012.04.007. Epub 2012 Jun 15.

Reference Type DERIVED
PMID: 22795281 (View on PubMed)

van Diepen S, Widimsky P, Lopes RD, White KR, Weaver WD, Van de Werf F, Ardissino D, van't Hof AW, Armstrong PW, Granger CB. Transfer times and outcomes in patients with ST-segment-elevation myocardial infarction undergoing interhospital transfer for primary percutaneous coronary intervention: APEX-AMI insights. Circ Cardiovasc Qual Outcomes. 2012 Jul 1;5(4):437-44. doi: 10.1161/CIRCOUTCOMES.112.965160. Epub 2012 May 15.

Reference Type DERIVED
PMID: 22589297 (View on PubMed)

Hudson MP, Armstrong PW, O'Neil WW, Stebbins AL, Weaver WD, Widimsky P, Aylward PE, Ruzyllo W, Holmes D, Mahaffey KW, Granger CB. Mortality implications of primary percutaneous coronary intervention treatment delays: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction trial. Circ Cardiovasc Qual Outcomes. 2011 Mar;4(2):183-92. doi: 10.1161/CIRCOUTCOMES.110.945311. Epub 2011 Feb 8.

Reference Type DERIVED
PMID: 21304097 (View on PubMed)

Huber K, Holmes DR Jr, van 't Hof AW, Montalescot G, Aylward PE, Betriu GA, Widimsky P, Westerhout CM, Granger CB, Armstrong PW. Use of glycoprotein IIb/IIIa inhibitors in primary percutaneous coronary intervention: insights from the APEX-AMI trial. Eur Heart J. 2010 Jul;31(14):1708-16. doi: 10.1093/eurheartj/ehq143. Epub 2010 May 25.

Reference Type DERIVED
PMID: 20501476 (View on PubMed)

Alhadramy O, Westerhout CM, Brener SJ, Granger CB, Armstrong PW; APEX AMI Investigators. Is visual interpretation of coronary epicardial flow reliable in patients with ST-elevation myocardial infarction undergoing primary angioplasty? Insights from the angiographic substudy of the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Am Heart J. 2010 May;159(5):899-904. doi: 10.1016/j.ahj.2010.02.028.

Reference Type DERIVED
PMID: 20435202 (View on PubMed)

Patel MR, Worthley SG, Stebbins A, Dill T, Rademakers FE, Valeti US, Barsness GW, Van de Werf F, Hamm CW, Armstrong PW, Granger CB, Kim RJ. Pexelizumab and infarct size in patients with acute myocardial infarction undergoing primary percutaneous coronary Intervention: a delayed enhancement cardiac magnetic resonance substudy from the APEX-AMI trial. JACC Cardiovasc Imaging. 2010 Jan;3(1):52-60. doi: 10.1016/j.jcmg.2009.09.014. Epub 2010 Jan 12.

Reference Type DERIVED
PMID: 20129531 (View on PubMed)

Trendelenburg M, Theroux P, Stebbins A, Granger C, Armstrong P, Pfisterer M. Influence of functional deficiency of complement mannose-binding lectin on outcome of patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Eur Heart J. 2010 May;31(10):1181-7. doi: 10.1093/eurheartj/ehp597. Epub 2010 Jan 19.

Reference Type DERIVED
PMID: 20089518 (View on PubMed)

Brener SJ, Westerhout CM, Fu Y, Todaro TG, Moliterno DJ, Wagner GS, Granger CB, Armstrong PW; APEX-AMI Investigators. Contribution of angiographic and electrocardiographic parameters of reperfusion to prediction of mortality and morbidity after acute ST-elevation myocardial infarction: Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction trial. Am Heart J. 2009 Nov;158(5):755-60. doi: 10.1016/j.ahj.2009.09.009. Epub 2009 Oct 3.

Reference Type DERIVED
PMID: 19853693 (View on PubMed)

Armstrong PW, Fu Y, Westerhout CM, Hudson MP, Mahaffey KW, White HD, Todaro TG, Adams PX, Aylward PE, Granger CB. Baseline Q-wave surpasses time from symptom onset as a prognostic marker in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention. J Am Coll Cardiol. 2009 Apr 28;53(17):1503-9. doi: 10.1016/j.jacc.2009.01.046.

Reference Type DERIVED
PMID: 19389560 (View on PubMed)

Buller CE, Fu Y, Mahaffey KW, Todaro TG, Adams P, Westerhout CM, White HD, van 't Hof AW, Van de Werf FJ, Wagner GS, Granger CB, Armstrong PW. ST-segment recovery and outcome after primary percutaneous coronary intervention for ST-elevation myocardial infarction: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Circulation. 2008 Sep 23;118(13):1335-46. doi: 10.1161/CIRCULATIONAHA.108.767772. Epub 2008 Sep 8.

Reference Type DERIVED
PMID: 18779444 (View on PubMed)

APEX AMI Investigators; Armstrong PW, Granger CB, Adams PX, Hamm C, Holmes D Jr, O'Neill WW, Todaro TG, Vahanian A, Van de Werf F. Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: a randomized controlled trial. JAMA. 2007 Jan 3;297(1):43-51. doi: 10.1001/jama.297.1.43.

Reference Type DERIVED
PMID: 17200474 (View on PubMed)

Other Identifiers

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2003056

Identifier Type: -

Identifier Source: org_study_id

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