Study of Olanzapine vs. Aripiprazole in the Treatment of Schizophrenia

NCT ID: NCT00088049

Last Updated: 2007-07-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

560 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-10-31

Study Completion Date

2007-07-31

Brief Summary

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The purpose of the protocol is to evaluate the efficacy of olanzapine compared with Aripiprazole in patients with schizophrenia.

Detailed Description

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Conditions

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Schizophrenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Olanzapine

Intervention Type DRUG

Aripiprazole

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female inpatient or outpatients, ages 18-65

Exclusion Criteria

* Participation in a clinical trial of another drug including olanzapine or aripiprazole within 30 days prior to study entry (visit 1).
* Treatment with clozapine within the past 12 months.
* Have known uncorrected narrow-angle glaucoma.
* Have a diagnosis of Parkinson's disease, dementia or related disorder
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. test

Little Rock, Arkansas, United States

Site Status

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. test

Garden Grove, California, United States

Site Status

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National City, California, United States

Site Status

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Orange, California, United States

Site Status

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Fort Lauderdale, Florida, United States

Site Status

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Hollywood, Florida, United States

Site Status

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Tampa, Florida, United States

Site Status

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Atlanta, Georgia, United States

Site Status

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Chicago, Illinois, United States

Site Status

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Oakbrook Terrace, Illinois, United States

Site Status

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New Orleans, Louisiana, United States

Site Status

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Glen Burnie, Maryland, United States

Site Status

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Minneapolis, Minnesota, United States

Site Status

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Brooklyn, New York, United States

Site Status

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Cedarhurst, New York, United States

Site Status

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New York, New York, United States

Site Status

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Rochester, New York, United States

Site Status

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Staten Island, New York, United States

Site Status

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Oklahoma City, Oklahoma, United States

Site Status

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Scranton, Pennsylvania, United States

Site Status

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. test

Charleston, South Carolina, United States

Site Status

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. test

Memphis, Tennessee, United States

Site Status

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. test

Austin, Texas, United States

Site Status

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. test

Salt Lake City, Utah, United States

Site Status

Countries

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United States

References

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Liu-Seifert H, Ascher-Svanum H, Osuntokun O, Jen KY, Gomez JC. Change in level of productivity in the treatment of schizophrenia with olanzapine or other antipsychotics. BMC Psychiatry. 2011 May 17;11:87. doi: 10.1186/1471-244X-11-87.

Reference Type DERIVED
PMID: 21586165 (View on PubMed)

Ascher-Svanum H, Stensland MD, Peng X, Faries DE, Stauffer VL, Osuntokun OO, Kane JM. Cost-effectiveness of olanzapine vs. aripiprazole in the treatment of schizophrenia. Curr Med Res Opin. 2011 Jan;27(1):115-22. doi: 10.1185/03007995.2010.537594. Epub 2010 Nov 26.

Reference Type DERIVED
PMID: 21110749 (View on PubMed)

Kane JM, Osuntokun O, Kryzhanovskaya LA, Xu W, Stauffer VL, Watson SB, Breier A. A 28-week, randomized, double-blind study of olanzapine versus aripiprazole in the treatment of schizophrenia. J Clin Psychiatry. 2009 Apr;70(4):572-81. doi: 10.4088/jcp.08m04421. Epub 2009 Mar 24.

Reference Type DERIVED
PMID: 19323965 (View on PubMed)

Other Identifiers

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F1D-MC-HGLB

Identifier Type: -

Identifier Source: secondary_id

8047

Identifier Type: -

Identifier Source: org_study_id