Efficacy and Safety of Seroquel Plus Mood Stabilizer in the Maintenance of Bipolar I Disorder

NCT ID: NCT00081380

Last Updated: 2008-12-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

710 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-03-31

Study Completion Date

2006-09-30

Brief Summary

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The purpose of this study is to determine whether quetiapine when used as adjunct to lithium or divalproex is safe and effective in the maintenance treatment of adult patients with Bipolar I Disorder. The study consists of enrollment and 2 phases, the Open-label treatment Phase and the Randomized treatment Phase.

PLEASE NOTE: Seroquel SR and Seroquel XR refer to the same formulation. The SR designation was changed to XR after consultation with FDA.

Detailed Description

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Conditions

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Bipolar Disorder

Keywords

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Bipolar I Disorder Manic Depressive Disorder Manic Depression, Mixed

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Interventions

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Seroquel®, quetiapine fumarate (atypical antipsychotic)

Intervention Type DRUG

lithium (mood stabilizer)

Intervention Type DRUG

divalproex (mood stabilizer)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Open-Label

* A diagnosis of Bipolar I Disorder, Most recent episode Manic (296.4x), or Bipolar I Disorder, Most Recent Episode Depressed (296.5x), or Bipolar I Disorder, Most recent Episode Mixed (296.6x), with or without psychotic features, as defined by Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition (DSM-IV)
* At least 1 manic, depressed, or mixed episode in the 2 years prior to the index episode.
* Able to understand and comply with the requirements of the study.

Exclusion Criteria

Open-Label

* Diagnosis of an anxiety disorder as defined by DSM-IV, which was treated with medication within the past year.
* Known intolerance or lack of response to quetiapine fumarate or to the assigned mood stabilizer, as judged by the investigator.
* Previously randomized into this study or D1447C00126
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Principal Investigators

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AstraZeneca Seroquel Medical Science Director, MD

Role: STUDY_DIRECTOR

AstraZeneca

Locations

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Birmingham, Alabama, United States

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Scottsdale, Arizona, United States

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Little Rock, Arkansas, United States

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Anaheim, California, United States

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Cerritos, California, United States

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Chula Vista, California, United States

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Culver City, California, United States

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Garden Grove, California, United States

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La Mesa, California, United States

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Oceanside, California, United States

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Orange, California, United States

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Pico Rivera, California, United States

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Riverside, California, United States

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Rosemead, California, United States

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San Diego, California, United States

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San Francisco, California, United States

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Santa Ana, California, United States

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Farmington, Connecticut, United States

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New Britain, Connecticut, United States

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Jacksonville, Florida, United States

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Miami, Florida, United States

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Orlando, Florida, United States

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West Palm Beach, Florida, United States

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Winter Park, Florida, United States

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Atlanta, Georgia, United States

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Decatur, Georgia, United States

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Marietta, Georgia, United States

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Smyrna, Georgia, United States

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Honolulu, Hawaii, United States

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Chicago, Illinois, United States

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Hoffman Estates, Illinois, United States

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Joliet, Illinois, United States

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Evansville, Indiana, United States

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Greenwood, Indiana, United States

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Indianapolis, Indiana, United States

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Wichita, Kansas, United States

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Florence, Kentucky, United States

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Lake Charles, Louisiana, United States

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New Orleans, Louisiana, United States

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Shreveport, Louisiana, United States

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Baltimore, Maryland, United States

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Rockville, Maryland, United States

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Pittsfield, Massachusetts, United States

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New Baltimore, Michigan, United States

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St Louis, Missouri, United States

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Clementon, New Jersey, United States

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Moorestown, New Jersey, United States

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West Caldwell, New Jersey, United States

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Albuquerque, New Mexico, United States

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Brooklyn, New York, United States

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New York, New York, United States

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The Bronx, New York, United States

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Butner, North Carolina, United States

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Raleigh, North Carolina, United States

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Beachwood, Ohio, United States

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Cincinnati, Ohio, United States

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Dayton, Ohio, United States

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Medina, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Tulsa, Oklahoma, United States

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Eugene, Oregon, United States

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Portland, Oregon, United States

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Emmaus, Pennsylvania, United States

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Moon Township, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Charleston, South Carolina, United States

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Memphis, Tennessee, United States

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Austin, Texas, United States

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Dallas, Texas, United States

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DeSoto, Texas, United States

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Houston, Texas, United States

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Irving, Texas, United States

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San Antonio, Texas, United States

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Wichita Falls, Texas, United States

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Charlottesville, Virginia, United States

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Falls Church, Virginia, United States

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Richmond, Virginia, United States

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Virginia Beach, Virginia, United States

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Bellevue, Washington, United States

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Kirkland, Washington, United States

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Morgantown, West Virginia, United States

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Edmonton, Alberta, Canada

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Vancouver, British Columbia, Canada

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Victoria, British Columbia, Canada

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Winnipeg, Manitoba, Canada

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Halifax, Nova Scotia, Canada

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Hamilton, Ontario, Canada

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Kingston, Ontario, Canada

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Markham, Ontario, Canada

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Mississauga, Ontario, Canada

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Oshawa, Ontario, Canada

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Toronto, Ontario, Canada

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Montreal, Quebec, Canada

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Québec, Quebec, Canada

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Countries

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United States Canada

References

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Suppes T, Vieta E, Gustafsson U, Ekholm B. Maintenance treatment with quetiapine when combined with either lithium or divalproex in bipolar I disorder: analysis of two large randomized, placebo-controlled trials. Depress Anxiety. 2013 Nov;30(11):1089-98. doi: 10.1002/da.22136. Epub 2013 Jun 12.

Reference Type DERIVED
PMID: 23761037 (View on PubMed)

Other Identifiers

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D1447C00127

Identifier Type: -

Identifier Source: org_study_id