Gender, Obesity, C-Reactive Protein, and Oxidative Stress
NCT ID: NCT00079963
Last Updated: 2017-09-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
396 participants
INTERVENTIONAL
2004-04-30
2008-03-24
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
QUADRUPLE
Study Groups
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X
Vitamin C
Vitamin C
1000 mg/day
Y
Vitamin E
Vitamin E
800 IU/day
Z
Placebo
Placebo
Interventions
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Vitamin C
1000 mg/day
Vitamin E
800 IU/day
Placebo
Eligibility Criteria
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Inclusion Criteria
* Males and females 18 year and older
* Able to take vitamin supplements
* Able to take acetominophen instead of aspirin or NSAIDs during the study
Exclusion Criteria
* History of ever smoking or passive smoke exposure in the last year
* Active liver disease; history of HIV/AIDS, diabetes, kidney stones, hemochromatosis, or autoimmune diseases; heart disease, stroke, or cancer in the last 5 years
* User of prescribed anti-inflammatory or lipid-lowering medications, oral contraceptives, hormone replacement therapy, or blood-thinning drugs
* User of iron supplements or vitamin E at 600 IU per day or more
* Consumption of more than 2 alcoholic beverages per day
18 Years
ALL
Yes
Sponsors
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University of California, Berkeley
OTHER
Kaiser Permanente
OTHER
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Responsible Party
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Principal Investigators
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Gladys Block, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of California at Berkeley
Locations
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University of California, Berkeley School of Public Health
Berkeley, California, United States
Countries
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References
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Block G, Jensen CD, Morrow JD, Holland N, Norkus EP, Milne GL, Hudes M, Dalvi TB, Crawford PB, Fung EB, Schumacher L, Harmatz P. The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level. Free Radic Biol Med. 2008 Aug 15;45(4):377-84. doi: 10.1016/j.freeradbiomed.2008.04.005. Epub 2008 Apr 16.
Block G, Shaikh N, Jensen CD, Volberg V, Holland N. Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1. Am J Clin Nutr. 2011 Sep;94(3):929-37. doi: 10.3945/ajcn.111.011460. Epub 2011 Aug 3.
Other Identifiers
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62378DK
Identifier Type: -
Identifier Source: org_study_id