Safety and Efficacy of INGAP-Peptide in Patients With Type 1 Diabetes

NCT ID: NCT00071409

Last Updated: 2014-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

63 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-10-31

Study Completion Date

2004-05-31

Brief Summary

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Insulin is a chemical that the body needs in order to use or store sugar. It is made by a type of cell called a beta cell which resides in an organ known as the pancreas. Type 1 diabetes is a disease where the beta cells have been destroyed so that little or no insulin is made. Sugar levels rise in the blood as a result. INGAP-Peptide is being tested to attempt to create new beta cells in the pancreas, and to restore the ability to produce insulin in type 1 diabetic patients.

Detailed Description

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Conditions

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Diabetes Mellitus, Insulin-Dependent

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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placebo

1.5 mL SC injection

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

1.5 mL, once daily, self-administered SC injection for 90 days

300 mg INGAP Peptide

1.5 mL SC injection, once daily for 90 days

Group Type EXPERIMENTAL

INGAP-Peptide

Intervention Type DRUG

1.5 mL, once daily, self-administered SC injection for 90 days

600 mg INGAP Peptide

1.5 mL SC injection, once daily for 90 days

Group Type EXPERIMENTAL

INGAP-Peptide

Intervention Type DRUG

1.5 mL, once daily, self-administered SC injection for 90 days

Interventions

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INGAP-Peptide

1.5 mL, once daily, self-administered SC injection for 90 days

Intervention Type DRUG

INGAP-Peptide

1.5 mL, once daily, self-administered SC injection for 90 days

Intervention Type DRUG

placebo

1.5 mL, once daily, self-administered SC injection for 90 days

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age 18-65
* fasting C-peptide \<0.3 ng/ml.
* HbA1c \<10%
* history of onset of type 1 DM at or before 20 years of age.
* Otherwise healthy
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Exsulin Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Procter and Gamble Pharmaceuticals

Locations

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Radiant Research

Irvine, California, United States

Site Status

VA Hospital UCSD

San Diego, California, United States

Site Status

Diablo Clinical Research

Walnut Creek, California, United States

Site Status

MedStar Clinical Research Center

Washington D.C., District of Columbia, United States

Site Status

Springfield Diabetes and Endocrine Center

Springfield, Illinois, United States

Site Status

Mercury Street Medical

Butte, Montana, United States

Site Status

UNC Diabetes Care Center

Durham, North Carolina, United States

Site Status

Clinical Research Institute of Southern Oregon

Medford, Oregon, United States

Site Status

University of Texas Health Science Center - Texas Diabetes Institute

San Antonio, Texas, United States

Site Status

DGD Research Associates

San Antonio, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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2003068

Identifier Type: -

Identifier Source: org_study_id

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