Delaying Alzheimer Disease Symptoms With Anti-Inflammatory Drugs

NCT ID: NCT00065169

Last Updated: 2020-03-02

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 138 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2000-11-30
• Study Completion Date: 2005-11-30

Brief Summary

The purpose of this study is to determine whether the anti-inflammatory drug celecoxib can delay the onset of Alzheimer Disease (AD) in people with Age Associated Memory Impairment (AAMI). This study will also evaluate genetic risk and brain structure as potential predictors of mental decline.

Detailed Description

AD is one of the most common mental disorders of late life. Preliminary studies indicate that anti-inflammatory drugs may attenuate or prevent AD symptoms, but efficacy trials are needed.

Participants in this study will be randomly assigned to receive either celecoxib or placebo for 18 months. Participants will undergo positron emission tomography (PET) and magnetic resonance imaging (MRI) scans of the brain. Routine laboratory blood tests, cognitive tests, and an electrocardiogram (ECG) will be performed. Participants will also be screened for Parkinson disease. Follow-up testing will be conducted at specific intervals following the study.

Conditions

Alzheimer Disease; Dementia

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: DOUBLE

Interventions

Celecoxib

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• NIMH diagnostic criteria for Age Associated Memory Impairment (AAMI)
• Mini-Mental State Examination (MMSE) score between 26 and 30 (unless < 8 years of educational achievement)
• No significant cerebrovascular disease
• Estrogen replacement therapy and thyroid replacement therapy (if the participant is euthyroid) are permitted if the therapies are stable for > 1 month
• Memory and verbal fluency cut-off scores that increase the probability of incipient dementia (Buschke-Fuld: 34; verbal fluency: 46 for letters, 7 for categories; Benton Visual Retention: 5)
• Adequate visual and auditory acuity to allow neuropsychological testing
• Normal screening laboratory tests and electrocardiogram (ECG)

Exclusion Criteria

• Possible or probable Alzheimer Disease (AD) or other dementia
• Neurologic or other physical illness that could produce cognitive deterioration
• History of transient ischemic attacks (TIAs), carotid bruits, or lacunes on an MRI scan
• History of myocardial infarction within the previous year or unstable cardiac disease
• Uncontrolled hypertension (systolic BP > 170 or diastolic BP > 100)
• History of significant liver disease, pulmonary disease, diabetes, or cancer
• DSM-IV criteria for major psychiatric disorders within the previous 2 years
• Past or present history of alcoholism or drug dependence
• Untreated depression as determined by a Hamilton Depression Rating Scale (HAM-D) score of 12 or more
• Drugs that may significantly affect psychometric test results
• Centrally active beta-blockers, narcotics, clonidine, anti-Parkinsonian medications, antipsychotics, benzodiazepines, systemic corticosteroids, medications with significant cholinergic or anticholinergic effects, anti-convulsants, warfarin, vitamins other than the standard multivitamin supplement, ginkgo biloba, and any nutraceuticals. Occasional chloral hydrate use will be allowed, but discouraged, for insomnia.
• Investigational drugs within the previous month or longer, depending on drug half-life
• Contraindication for MRI scan (e.g., metal in body, claustrophobia)

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Institute of Mental Health (NIMH)

NIH

Sponsor Role: collaborator

University of California, Los Angeles

OTHER

Sponsor Role: lead

Responsible Party

Gary Small, MD

UCLA Professor of Psychiatry and Biobehavioral Sciences

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

UCLA Neuropsychiatric Institute

Los Angeles, California, United States

Countries

United States

Other Identifiers

R01MH058156

Identifier Type: NIH

Identifier Source: secondary_id

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DSIR AT-GP

Identifier Type: -

Identifier Source: secondary_id

R01MH058156

Identifier Type: NIH

Identifier Source: org_study_id

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