Evaluation of the Safety of and Immune Response to an HIV Vaccine in Healthy Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-03-31

Study Completion Date

2005-02-28

Brief Summary

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This study will examine the safety and immune response to a two-part HIV vaccine. Healthy volunteers who are at low risk of HIV infection will receive either active vaccine or a placebo.

Detailed Description

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The purpose of this study is to examine the safety and immunogenicity of a candidate vaccine strategy for HIV prophylaxis using a DNA-prime plus recombinant fowlpox boost. The DNA plasmid and fowlpox vector contain HIV genes. However, these vaccines contain only some HIV genes and cannot themselves cause HIV or AIDS.

Eligible volunteers at low risk of HIV infection will be randomized to receive either active vaccine or placebo injections at Day 0, Week 4, and Week 8. Intensive immunologic and safety monitoring will be done during the first 16 weeks of the study. Follow-up will continue to Week 52.

Conditions

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HIV Infections

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Interventions

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HIV DNA plasmid vaccine plus recombinant fowlpox vector

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* HIV negative.
* Acceptable methods of contraception.

Exclusion Criteria

* Identifiable risk behavior for HIV infection, including: sexual partners of HIV positive people, sexual intercourse with a partner of unknown HIV status if that partner is reported to be at higher risk for HIV infection, gay men reporting any unprotected anal intercourse with partners of unknown status in the 12 months preceding study entry, individuals diagnosed with a sexually transmissible infection (STI) in the 12 months preceding entry that may have been acquired through anal or vaginal intercourse, individuals reporting sharing of injecting equipment in the last 12 months.
* HIV candidate vaccines in a previous HIV vaccine trial.
* Live attenuated vaccines within 60 days prior to entering the study. Whole killed, toxoid, or sub-unit vaccines (e.g., influenza, pneumococcal, tetanus, and hepatitis B) are not exclusionary within 4 weeks prior to the scheduled experimental HIV vaccines.
* Hypersensitivity to egg products or a known history of anaphylaxis or any other serious adverse reactions to vaccination.
* History of serious allergic reaction requiring hospitalization or emergency medical care (e.g., Stevens-Johnson syndrome, bronchospasm, or hypotension) to any substance.
* Significant illness requiring immunomodulatory or cytotoxic therapy.
* History of cancer unless there is evidence of surgical excision followed by a sufficient observation period to give a reasonable assurance of cure.
* Blood products or immunoglobulins within 6 months prior to entering the study.
* Experimental or investigational agents within 30 days prior to entering the study.
* Recreational and/or therapeutic drug use that might compromise the study participant's safety.
* Medical or psychiatric condition or occupational responsibilities that preclude compliance with the protocol.
* Pregnant or lactating women.

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Principal Investigators

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David A Cooper, MD, DSc

Role: STUDY_DIRECTOR

National Centre in HIV Epidemiology and Clinical Research, University of New South Wales

Locations

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National Centre in HIV Epidemiology and Clinical Research

Sydney, New South Wales, Australia

Site Status

Countries

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Australia

References

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Kelleher AD, Puls RL, Bebbington M, Boyle D, Ffrench R, Kent SJ, Kippax S, Purcell DF, Thomson S, Wand H, Cooper DA, Emery S. A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1. AIDS. 2006 Jan 9;20(2):294-7. doi: 10.1097/01.aids.0000199819.40079.e9.

Reference Type RESULT

PMID: 16511428 (View on PubMed)

Other Identifiers

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N01-AI05395

Identifier Type: -

Identifier Source: org_study_id