Olanzapine Versus Placebo in the Treatment of Adolescents With Schizophrenia

NCT ID: NCT00051298

Last Updated: 2007-06-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

107 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-11-30

Study Completion Date

2005-04-30

Brief Summary

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This study is to determine the efficacy (how well the drug works), safety, and any side effects of olanzapine compared to placebo in the treatment of schizophrenia in adolescents. Both the potential benefits and side effects of olanzapine will be evaluated throughout this trial.

Detailed Description

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Conditions

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Schizophrenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Olanzapine

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Are male or female patients, 13 to 17 years of age
* Patients must have a diagnosis of schizophrenia per DSM-IV-TR.
* Female patients of child-bearing potential must test negative for pregnancy at the time of enrollment.
* Both the patient and the patient's parent/authorized legal representative must understand the nature of the study and must sign a document granting consent.
* Patients must be capable of swallowing study medication whole (without crushing, dissolving, etc.)

Exclusion Criteria

* Female patients who are either pregnant or nursing.
* Patients with acute or unstable medical conditions.
* Patients who have been judged clinically to be at serious suicidal risks.
* Patients who have previously not responded to an adequate dose and/or duration of olanzapine treatment.
* Patients who currently have delusional disorder, psychotic disorder NOS, schizophreniform, schizoaffective disorder, bipolar disorder, attention deficit/hyperactivity disorder or major depressive disorder.
Minimum Eligible Age

13 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon-Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hrs, EST), or speak with your personal physician.

Little Rock, Arkansas, United States

Site Status

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Cerritos, California, United States

Site Status

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San Diego, California, United States

Site Status

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Washington D.C., District of Columbia, United States

Site Status

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Jacksonville, Florida, United States

Site Status

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North Miami, Florida, United States

Site Status

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Atlanta, Georgia, United States

Site Status

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Chicago, Illinois, United States

Site Status

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Indianapolis, Indiana, United States

Site Status

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Lake Charles, Louisiana, United States

Site Status

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Bangor, Maine, United States

Site Status

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Minneapolis, Minnesota, United States

Site Status

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Chesterfield, Missouri, United States

Site Status

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Las Vegas, Nevada, United States

Site Status

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Cherry Hill, New Jersey, United States

Site Status

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New York, New York, United States

Site Status

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Rochester, New York, United States

Site Status

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Beachwood, Ohio, United States

Site Status

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Cincinnati, Ohio, United States

Site Status

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Hershey, Pennsylvania, United States

Site Status

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Madison, Tennessee, United States

Site Status

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Bellaire, Texas, United States

Site Status

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Salt Lake City, Utah, United States

Site Status

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Kirkland, Washington, United States

Site Status

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Moscow, , Russia

Site Status

Countries

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United States Russia

References

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Kryzhanovskaya LA, Robertson-Plouch CK, Xu W, Carlson JL, Merida KM, Dittmann RW. The safety of olanzapine in adolescents with schizophrenia or bipolar I disorder: a pooled analysis of 4 clinical trials. J Clin Psychiatry. 2009 Feb;70(2):247-58. doi: 10.4088/jcp.08m03538. Epub 2009 Feb 10.

Reference Type DERIVED
PMID: 19210948 (View on PubMed)

Kryzhanovskaya L, Schulz SC, McDougle C, Frazier J, Dittmann R, Robertson-Plouch C, Bauer T, Xu W, Wang W, Carlson J, Tohen M. Olanzapine versus placebo in adolescents with schizophrenia: a 6-week, randomized, double-blind, placebo-controlled trial. J Am Acad Child Adolesc Psychiatry. 2009 Jan;48(1):60-70. doi: 10.1097/CHI.0b013e3181900404.

Reference Type DERIVED
PMID: 19057413 (View on PubMed)

Other Identifiers

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F1D-MC-HGIN

Identifier Type: -

Identifier Source: secondary_id

4066

Identifier Type: -

Identifier Source: org_study_id