STOP Trial - Sandostatin LAR Depot Trial for the Optimum Prevention of Chemotherapy Induced Diarrhea

NCT ID: NCT00050635

Last Updated: 2009-11-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-12-31

Study Completion Date

2003-07-31

Brief Summary

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Currently there is an ongoing clinical trial for patients with chemotherapy induced diarrhea. This trial is being conducted to evaluate the efficacy of two dose levels (30 mg and 40 mg) of an investigational drug in reducing the occurrence of severe (Grade 3 or 4) diarrhea during chemotherapy. Eligible patients must either have experienced NCI Common Toxicity Grade 1 - 4 chemotherapy-induced diarrhea during previous chemotherapy treatment or be experiencing Grade 1-4 chemotherapy-induced diarrhea currently.

In order to participate in this clinical trial, patients must be male or female 18 years of age or older. Inclusion into this investigational drug trial is based on the protocol entry criteria and a detailed evaluation from a participating trial investigator

Detailed Description

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Conditions

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Neoplasms Diarrhea

Keywords

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chemotherapy induced diarrhea diarrhea CTID colorectal cancer Sandostatin LAR Depot Sandostatin adverse events side effects

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Interventions

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Sandostatin LAR Depot

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* male or female patients of 18 years of age or older, scheduled or expected to receive at least two cycles of chemotherapy over at least a two- month period as primary or adjuvant therapy for any malignancy,
* have experienced NCI Common Toxicity Grade 1 - 4 diarrhea during previous chemotherapy treatment or are currently experiencing Grade 1-4 diarrhea due to chemotherapy treatment

Exclusion Criteria

* females who are pregnant or lactating,
* current use of anticoagulants, except for those who are receiving 1 mg/per day of Coumadin for port maintenance,
* known hypersensitivity to Sandostatin, Sandostatin LAR ® Depot or other related drug or compound,
* history or presence of Crohn™s disease, ulcerative colitis, sprue, or known C. difficile infection, or any other diarrheal syndrome,
* WBC \< 3000 /L, Platelets \< 75,000 /L, serum creatinine \>2.0 mg/dL
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Quintiles, Inc.

INDUSTRY

Sponsor Role collaborator

Novartis Pharmaceuticals

INDUSTRY

Sponsor Role lead

Locations

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Kenmar Research Institute

Burbank, California, United States

Site Status

Bay Area Cancer Research Group

Concord, California, United States

Site Status

Compassionate Cancer Care medical Group, Inc.

Fountain Valley, California, United States

Site Status

California Cancer Care, Inc.

Greenbrae, California, United States

Site Status

Pacific Shores Medical Center

Long Beach, California, United States

Site Status

Kenmar Research Institute

Los Angeles, California, United States

Site Status

Oncology Hematology Group of South Florida

Miami, Florida, United States

Site Status

Pasco Hernando Oncology Associates

New Port Richey, Florida, United States

Site Status

Mid-Florida Hematology & Oncology Centers, PA

Orange City, Florida, United States

Site Status

Oncology & Hematology Associates of West Broward

Tamarac, Florida, United States

Site Status

Creticos Cancer Center

Chicago, Illinois, United States

Site Status

Decatur Memorial Hospital

Decatur, Illinois, United States

Site Status

Cancer Care Center

Bloomington, Indiana, United States

Site Status

Suniti Medical Corporation

Merrillville, Indiana, United States

Site Status

Genesys Hurley Cancer Institute

Flint, Michigan, United States

Site Status

Cancer & Hematology Centers of Western Michigan

Grand Rapids, Michigan, United States

Site Status

Delta Oncology

Greenwood, Mississippi, United States

Site Status

Missouri Cancer Associates

Columbia, Missouri, United States

Site Status

Heartland Hematology Oncology Associates

Kansas City, Missouri, United States

Site Status

Arch Medical Services/The Center for Cancer Care and Research

St Louis, Missouri, United States

Site Status

New Mexico Cancer Care Associates

Santa Fe, New Mexico, United States

Site Status

North Shore Hematology Oncology

East Setauket, New York, United States

Site Status

Raleigh Hematology Oncology Associates, Wake Practice

Raleigh, North Carolina, United States

Site Status

Dakota Clinic/Odyssey Research Services

Fargo, North Dakota, United States

Site Status

Nashat Y. Gabrail, MD

Canton, Ohio, United States

Site Status

North Coast Cancer Care, Inc.

Sandusky, Ohio, United States

Site Status

Lawrence M. Stallings, MD

Wooster, Ohio, United States

Site Status

Consultants in Medical Oncology-Hematology

Drexel Hill, Pennsylvania, United States

Site Status

Regional Hematology Oncology Assoc

Langhorne, Pennsylvania, United States

Site Status

Oncology Services of Aberdeen

Borden, South Dakota, United States

Site Status

Jones Oncolgy/Hematology Clinic

Germantown, Tennessee, United States

Site Status

McFaddin Ward Cancer - TOPA

Beaumont, Texas, United States

Site Status

Scott & White Hospital/CCPC

Waco, Texas, United States

Site Status

Oncology & Hematology Associates of SW VA

Roanoke, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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STOP Trial

Identifier Type: -

Identifier Source: secondary_id

CSMS995AUS38

Identifier Type: -

Identifier Source: org_study_id