A Study of Xeloda (Capecitabine) in Patients With Advanced and/or Metastatic Colorectal Cancer

NCT ID: NCT00048139

Last Updated: 2016-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

52 participants

Study Classification

INTERVENTIONAL

Study Start Date

2001-10-31

Study Completion Date

2005-06-30

Brief Summary

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This study will assess the efficacy and safety of intermittent oral Xeloda administration in combination with irinotecan as a first-line treatment in patients with advanced and/or metastatic colorectal cancer. The anticipated time on study treatment is 3-12 months and the target sample size is \<100 individuals.

Detailed Description

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Conditions

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Colorectal Cancer

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

Irinotecan

Intervention Type DRUG

250mg/m2 iv on day 1 of each 3 week cycle

capecitabine [Xeloda]

Intervention Type DRUG

1000mg/m2 po bid on days 1-15 of each 3 week cycle

Interventions

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Irinotecan

250mg/m2 iv on day 1 of each 3 week cycle

Intervention Type DRUG

capecitabine [Xeloda]

1000mg/m2 po bid on days 1-15 of each 3 week cycle

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* adult patients \>=18 years of age;
* locally advanced and/or metastatic colorectal cancer;
* \>=1 target lesion.

Exclusion Criteria

* previous treatment with Xeloda or irinotecan;
* previous systemic therapy for metastatic disease;
* progressive disease during previous adjuvant therapy or within 6 months of completion.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Phoenix, Arizona, United States

Site Status

Fountain Valley, California, United States

Site Status

La Jolla, California, United States

Site Status

Santa Rosa, California, United States

Site Status

Denver, Colorado, United States

Site Status

Hutchinson, Kansas, United States

Site Status

Las Vegas, Nevada, United States

Site Status

Albuquerque, New Mexico, United States

Site Status

Albuquerque, New Mexico, United States

Site Status

Buffalo, New York, United States

Site Status

Houston, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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MO16461

Identifier Type: -

Identifier Source: org_study_id