Nasal Irritation Study: Individual Factors in Nasal Irritant Sensitivity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

64 participants

Study Classification

INTERVENTIONAL

Study Start Date

2000-09-30

Brief Summary

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This study seeks to document differences in nasal irritant sensitivity within the population. The investigators are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called "problem buildings"), as well as in understanding the reflex mechanism of a response of the nose to irritants (e.g., nasal congestion).

Detailed Description

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Conditions

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Rhinitis, Allergic, Nonseasonal

Keywords

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rhinitis irritation trigeminal

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

SINGLE

Interventions

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Nasal irritation thresholds and irritant provocation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Non-smokers
* 18-69 years of age
* With or without allergic rhinitis (hay fever)
* In good general health and with no prior history of asthma

Minimum Eligible Age

18 Years

Maximum Eligible Age

69 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Locations

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Upper Airway Biology Laboratory

Richmond, California, United States

Site Status

Countries

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United States

References

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Shusterman DJ, Murphy MA, Balmes JR. Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):732-40. doi: 10.1016/S0091-6749(98)70302-1.

Reference Type BACKGROUND

PMID: 9648699 (View on PubMed)

Shusterman D, Murphy MA, Balmes J. The influence of sex, allergic rhinitis, and test system on nasal sensitivity to airborne irritants: a pilot study. Environ Health Perspect. 2001 Jan;109(1):15-9. doi: 10.1289/ehp.0110915.