Effects of St. John's Wort on the Effectiveness of Oral Contraceptives

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-01-31

Study Completion Date

2004-01-31

Brief Summary

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The purpose of this study is to evaluate the effects of a common herbal remedy, St. John's Wort, on the effectiveness of birth control pills. St. John's Wort has recently been shown to increase metabolism of some drugs. If it could increase metabolism of oral contraceptives as well, it may increase the risk of contraceptive failure and unintended pregnancy. Study participants will be evaluated for risk of ovulation on oral contraceptives before and during simultaneous therapy with St. John's Wort.

Detailed Description

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See Brief Summary

Conditions

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Contraception

Keywords

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contraception hormonal contraception herbal remedies hypericum perforatum contraceptive effectiveness

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Interventions

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hypericum perforatum

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Women taking or willing to take low dose oral contraceptives for 5 months
* No contraindications to hormonal contraception

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Principal Investigators

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Patricia Murphy, DrPh

Role: PRINCIPAL_INVESTIGATOR

Columbia University

Locations

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Columbia University Department of Obstetrics & Gynecology

New York, New York, United States

Site Status

Countries

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United States

Other Identifiers

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R21AT000836-01

Identifier Type: NIH

Identifier Source: org_study_id

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