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Pesticides--Health Fertility and Reproductive Risk

NCT ID: NCT00015561

Last Updated: 2006-09-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1803 participants

Study Classification

OBSERVATIONAL

Study Start Date

1996-09-30

Study Completion Date

2001-08-31

Brief Summary

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This project is designed to establish whether pesticides or other environmental agents have a role in the excess birth defects identified in the Red River Valley of Minnesota. In this human study, laboratory based health parameters will be used to key in health survey data. In vitro data will be developed to mechanistic information. Concordant results among these study features will provide a weight of evidence approach.

Detailed Description

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Conditions

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Birth Defects Miscarriages Cancer

Keywords

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population studies laboratory evaluation hormone analysis semen analysis chromosome studies

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

Pesticide applicators and their spouses
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Environmental Health Sciences (NIEHS)

NIH

Sponsor Role lead

Principal Investigators

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Vincent F Garry, MD

Role: PRINCIPAL_INVESTIGATOR

University of Minnesota

Locations

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University of Minnesota Medical School

Minneapolis, Minnesota, United States

Site Status

Countries

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United States

References

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Lyubimov AV, Garry VF, Carlson RE, Barr DB, Baker SE. Simplified urinary immunoassay for 2,4-D: validation and exposure assessment. J Lab Clin Med. 2000 Aug;136(2):116-24. doi: 10.1067/mlc.2000.108150.

Reference Type BACKGROUND
PMID: 10945240 (View on PubMed)

Lin N, Garry VF. In vitro studies of cellular and molecular developmental toxicity of adjuvants, herbicides, and fungicides commonly used in Red River Valley, Minnesota. J Toxicol Environ Health A. 2000 Jul 28;60(6):423-39. doi: 10.1080/00984100050033494.

Reference Type BACKGROUND
PMID: 10933758 (View on PubMed)

Kirkhorn SR, Garry VF. Agricultural lung diseases. Environ Health Perspect. 2000 Aug;108 Suppl 4(Suppl 4):705-12. doi: 10.1289/ehp.00108s4705.

Reference Type BACKGROUND
PMID: 10931789 (View on PubMed)

Garry VF, Burroughs B, Tarone R, Kesner JS. Herbicides and adjuvants: an evolving view. Toxicol Ind Health. 1999 Jan-Mar;15(1-2):159-67. doi: 10.1191/074823399678846619.

Reference Type BACKGROUND
PMID: 10188198 (View on PubMed)

Schreinemachers DM, Creason JP, Garry VF. Cancer mortality in agricultural regions of Minnesota. Environ Health Perspect. 1999 Mar;107(3):205-11. doi: 10.1289/ehp.99107205.

Reference Type BACKGROUND
PMID: 10064550 (View on PubMed)

Other Identifiers

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8161-CP-001

Identifier Type: -

Identifier Source: org_study_id