Dichloroacetate Kinetics, Metabolism and Toxicology

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

1994-12-31

Study Completion Date

2002-10-31

Brief Summary

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Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.

Detailed Description

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Conditions

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Lactic Acidosis

Keywords

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Dichloroacetate Chlorinated hydrocarbons Genetic disease Toxicology Biotransformation

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

PROSPECTIVE

Interventions

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Dichloroacetate

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Children with congenital lactic acidosis Healthy adult volunteers

Minimum Eligible Age

3 Months

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Locations

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Univ. of Florida

Gainesville, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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7355-CP-001

Identifier Type: -

Identifier Source: org_study_id