Study of the Approximate Entropy of Adrenocorticotropic Hormone and Cortisol Secretion in Patients With Head Injury
NCT ID: NCT00006270
Last Updated: 2005-06-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
32 participants
OBSERVATIONAL
1998-02-28
Brief Summary
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II. Determine the correlation between randomness of ACTH and cortisol secretion and stages of sleep in these patients.
Detailed Description
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Admission 1: Patients receive cosyntropin IV. Blood is drawn at 30 and 60 minutes after IV infusion. Patients receive oral metyrapone before sleep. A sham sleep study is conducted through the night and patients' blood is drawn in the morning.
Admission 2: At least 2 weeks after admission 1, patients return for an overnight admission. Starting in the evening, blood is drawn every 15 minutes for 12 hours. A sleep study is conducted through the night.
Conditions
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Keywords
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Interventions
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cosyntropin
metyrapone
Eligibility Criteria
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Inclusion Criteria
--Disease Characteristics--
Patients who have sustained head injury
Closed head injury from trauma OR
Vascular accidents like strokes and hemorrhages
--Prior/Concurrent Therapy--
Endocrine therapy: No concurrent cortisol replacement
Other: No blood donation during and for 1 month after study
--Patient Characteristics--
Hematopoietic: Hemoglobin normal
Other:
* No hypopituitarism
* No body mass index of 28 or greater
* Not pregnant or nursing
* Must have normal menstrual cycles
* No severe mental impairment
* Must not require legal guardian
20 Years
35 Years
ALL
No
Sponsors
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University of Texas
OTHER
National Center for Research Resources (NCRR)
NIH
Principal Investigators
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Randall Urban
Role: STUDY_CHAIR
University of Texas
Locations
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Transitional Learning Community
Galveston, Texas, United States
University of Texas Medical Branch
Galveston, Texas, United States
Countries
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Other Identifiers
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UTMB-98-018
Identifier Type: -
Identifier Source: secondary_id
UTMB-GCRC-486
Identifier Type: -
Identifier Source: secondary_id
199/15376
Identifier Type: -
Identifier Source: org_study_id