The Effect of Estrogen and Progesterone Levels on Knee and Ankle Joint Laxity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Study Classification

OBSERVATIONAL

Brief Summary

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The proposed research is an observational study designed to compare estrogen and progesterone serum levels with knee and ankle joint laxity, and muscle reaction time as a measure of neuromuscular function. Three groups of women athletes with differing estrogen and progesterone profiles (normal menstrual cycles, amenorrheic, and exogenous estrogen supplementation) and one control group (male collegiate athletes) will be used to compare differences in joint laxity and neuromuscular function. Blood levels of estrogen and progesterone will be measured at four time points across the menstrual cycle. Joint laxity and muscle reaction time will also be measured at each of these points. The investigator hypothesizes that knee and ankle joint laxity and muscle reaction time will significantly increase with increasing estrogen and progesterone levels.

Detailed Description

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Conditions

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Healthy

Keywords

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Joint Instability

Study Design

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Observational Model Type

NATURAL_HISTORY

Eligibility Criteria

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Inclusion Criteria

* pre-collegiate or collegiate athletes

Minimum Eligible Age

15 Years

Maximum Eligible Age

23 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Locations

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University of Vermont

Burlington, Vermont, United States

Site Status

Countries

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United States

Other Identifiers

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M01RR000109

Identifier Type: NIH

Identifier Source: secondary_id

View Link

NCRR-M01RR00109-0749

Identifier Type: -

Identifier Source: org_study_id