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Dynamic Aspects of Amino Acid Metabolism

NCT ID: NCT00005767

Last Updated: 2005-06-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Study Classification

OBSERVATIONAL

Brief Summary

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This protocol seeks to define aspects of intestinal and hepatic uptake and metabolism of several amino acids. The major hypothesis to be tested is that the splanchic bed (intestine and liver) conserves essential amino acids and metabolites while synthesizing and metabolizing nonessential amino acids. The aims of the study include defining the relative roles of enteral and hepatic extraction/metabolism in the disposition of glutamate, alanine, methionine and other amino acids. Emphasis will also be placed on studies of the transamination of alpha-ketoisocaproic acid (KIC) to leucine since this reaction is of potential importance in the design of nutritional regimens for patients with renal disease.

Detailed Description

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Conditions

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Kidney Diseases

Keywords

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Amino Acid Metabolism

Study Design

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Observational Model Type

NATURAL_HISTORY

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* normal weight-for-height weight 50-80 kg
* normal physical activity
* no significant medical history
* healthy by medical exam and lab blood testing

Exclusion Criteria

* subjects who exercise vigorously
* subjects who smoke
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Center for Research Resources (NCRR)

NIH

Sponsor Role lead

Locations

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University of Vermont

Burlington, Vermont, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Dwight Matthews, Ph.D.

Role: CONTACT

Phone: 1-802-646-8114

Facility Contacts

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Dwight Matthews, Ph.D.

Role: primary

Other Identifiers

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M01RR000109

Identifier Type: NIH

Identifier Source: secondary_id

View Link

NCRR-M01RR00109-0740

Identifier Type: -

Identifier Source: org_study_id