Statistical Analysis of Vlagtwedde-Vlaardingen Data Set

NCT ID: NCT00005425

Last Updated: 2016-03-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Study Classification

OBSERVATIONAL

Study Start Date

1992-09-30

Study Completion Date

1995-02-28

Brief Summary

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To determine the effects in early adulthood of asthma, increased bronchial responsiveness, markers of allergy and smoking on pulmonary function level and the effects of these same risk factors on subsequent decline in pulmonary function, because these early adult factors presumably profoundly influence the risk for chronic obstructive pulmonary disease.

Detailed Description

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DESIGN NARRATIVE:

The questions studied included whether the above named risk factors reduced the maximally attained level of pulmonary function in early adulthood, foreshortened the postulated stability of level of pulmonary function between age 18 and 35 and/or unfavorably affected subsequent decline in level of pulmonary function. FEV1/h2, VC/h2 and FEV1/IVC were studied, using graphic smooth techniques and regression analyses techniques on both cross-sectional and longitudinal datasets. In addition, the investigators tested the hypothesis stating that early adult symptoms of asthma, increased bronchial responsiveness, markers of allergy influenced who became a smoker, influenced the amount smoked and/or influenced who stopped smoking relatively early in adult life, using logistic regression analyses and survival analyses.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Conditions

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Asthma Lung Diseases, Obstructive Chronic Obstructive Pulmonary Disease

Eligibility Criteria

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Inclusion Criteria

No eligibility criteria
Maximum Eligible Age

100 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role lead

References

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Shimada M, Matsumata T, Itasaka H, Shirabe K, Taketomi A, Sugimachi K. The prediction of portal pressure: a multivariate analysis of clinical data and intraoperative portal pressure. Surg Today. 1994;24(4):309-12. doi: 10.1007/BF02348558.

Reference Type BACKGROUND
PMID: 8038504 (View on PubMed)

Xu X, Weiss ST, Dockery DW, Schouten JP, Rijcken B. Comparing FEV1 in adults in two community-based studies. Chest. 1995 Sep;108(3):656-62. doi: 10.1378/chest.108.3.656.

Reference Type BACKGROUND
PMID: 7656612 (View on PubMed)

Rijcken B, Schouten JP, Xu X, Rosner B, Weiss ST. Airway hyperresponsiveness to histamine associated with accelerated decline in FEV1. Am J Respir Crit Care Med. 1995 May;151(5):1377-82. doi: 10.1164/ajrccm.151.5.7735588.

Reference Type BACKGROUND
PMID: 7735588 (View on PubMed)

Xu X, Laird N, Dockery DW, Schouten JP, Rijcken B, Weiss ST. Age, period, and cohort effects on pulmonary function in a 24-year longitudinal study. Am J Epidemiol. 1995 Mar 15;141(6):554-66. doi: 10.1093/oxfordjournals.aje.a117471.

Reference Type BACKGROUND
PMID: 7900723 (View on PubMed)

Other Identifiers

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R03HL049460

Identifier Type: NIH

Identifier Source: secondary_id

View Link

4343

Identifier Type: -

Identifier Source: org_study_id

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