Phase III Randomized Study of the Effect of Postmenopausal Estrogen Replacement Therapy on Alveolar Bone Loss
NCT ID: NCT00004650
Last Updated: 2005-06-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
150 participants
INTERVENTIONAL
1993-08-31
Brief Summary
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II. Evaluate the effects of estrogen on alveolar bone loss rates in these patients.
III. Determine whether changes in periodontal bone mass relate to bone mass changes in other skeletal sites in these patients.
Detailed Description
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Participants in the placebo group may be removed from study if bone loss exceeds 5% per year.
A study duration of 3 years is anticipated.
Conditions
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Study Design
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RANDOMIZED
TREATMENT
DOUBLE
Interventions
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conjugated estrogens
Medroxyprogesterone
Eligibility Criteria
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Inclusion Criteria
* Women postmenopausal for at least 2 years
* At least 10 teeth for which radiographic measurements can be obtained, i.e.: Not severely tilted Not so closely spaced that interproximal bone is thin Not in positions of restricted access
0 Years
FEMALE
No
Sponsors
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Washington University School of Medicine
OTHER
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Principal Investigators
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Charles F. Hildebolt
Role: STUDY_CHAIR
Washington University School of Medicine
References
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Hildebolt CF, Pilgram TK, Dotson M, Yokoyama-Crothers N, Muckerman J, Hauser J, Cohen S, Kardaris E, Vannier MW, Hanes P, Shrout MK, Civitelli R. Attachment loss with postmenopausal age and smoking. J Periodontal Res. 1997 Oct;32(7):619-25. doi: 10.1111/j.1600-0765.1997.tb00940.x.
Hildebolt CF. Osteoporosis and oral bone loss. Dentomaxillofac Radiol. 1997 Jan;26(1):3-15. doi: 10.1038/sj.dmfr.4600226.
Hildebolt CF, Brunsden B, Yokoyama-Crothers N, Pilgram TK, Townsend KE, Vannier MW, Shrout MK. Comparison of reliability of manual and computer-intensive methods for radiodensity measures of alveolar bone loss. Dentomaxillofac Radiol. 1998 Jul;27(4):245-50. doi: 10.1038/sj/dmfr/4600352.
Other Identifiers
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WUSM-900449
Identifier Type: -
Identifier Source: secondary_id
199/11726
Identifier Type: -
Identifier Source: org_study_id