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Longitudinal and Biological Study of Childhood Disintegrative Disorder

NCT ID: NCT00004458

Last Updated: 2005-06-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

220 participants

Study Classification

OBSERVATIONAL

Study Start Date

1997-05-31

Brief Summary

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OBJECTIVES:

I. Compare the developmental course (language acquisition, diagnostic stability, predictors of outcome, and restricted interests and behaviors) of childhood disintegrative disorder versus autism and non-autistic developmental delays.

II. Collect data on molecular genetics of proband and family members.

Detailed Description

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PROTOCOL OUTLINE:

Patients are evaluated with the following questionnaires at ages 2-3 years and again at ages 5-9: The Autism Diagnostic Interview (ADI); The Autism Diagnostic Observation Schedule (ADOS); Assessment of cognitive functioning; Expressive and receptive language; Adaptive functioning; Measures of burden and functional assessment; The Aberrant Behavior Checklist; The Connors Rating Scale - Parent and Teacher version; and Autism Behavior Checklist

An MRI and EEG are performed, and blood samples are collected from patients and family members for molecular genetic studies.

Conditions

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Pervasive Child Development Disorders Autism

Study Design

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Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* Psychologically diagnosed (DSM-IV) as Childhood Disintegrative Disorder
* No known genetic or medical syndrome (Down syndrome or cerebral palsy)
* Must speak English
Minimum Eligible Age

2 Years

Maximum Eligible Age

9 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Yale University

OTHER

Sponsor Role collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

Sponsor Role lead

Principal Investigators

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Fred Volkmar

Role: STUDY_CHAIR

Yale University

Locations

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Yale Child Study Center

New Haven, Connecticut, United States

Site Status

University of Chicago Cancer Research Center

Chicago, Illinois, United States

Site Status

Countries

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United States

References

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Volkmar FR, Klin A, Marans WD, et al.: Childhood disintegrative disorder. In: Cohen DJ, Volkmar FR.: Handbook of autism and pervasive developmental disorders. 2nd ed., New York, NY: John Wiley, 1997, pp 47-59.

Reference Type BACKGROUND

Other Identifiers

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YALE-5P01HD0300830

Identifier Type: -

Identifier Source: secondary_id

YALE-HIC-5895

Identifier Type: -

Identifier Source: secondary_id

199/13682

Identifier Type: -

Identifier Source: org_study_id