Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

35 participants

Study Classification

OBSERVATIONAL

Study Start Date

1978-12-31

Brief Summary

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OBJECTIVES: I. Study the metabolism of pyruvate and related problems in patients with lactic acidemia.

II. Define the nature of the metabolic defect.

Detailed Description

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PROTOCOL OUTLINE: Patients fast for 6 hours. Glucagon IM is administered after the 6 hour fast. Glucose level is measured at 0, 15, 30, 45, 60, and 90 minutes.

In children of sufficient size, alanine and lactic acid should also be measured at each or most of these time points.

Fasting continues for at least 18 hours. Glucagon IM is administered again at end of fast. Glucose level is measured at time 0, 15, 30, 45, 60, and 90 minutes.

Conditions

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Mitochondrial Myopathy MELAS Syndrome Lactic Acidosis

Keywords

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MELAS syndrome inborn errors of metabolism lactic acidosis mitochondrial myopathy rare disease

Eligibility Criteria

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Inclusion Criteria

PROTOCOL ENTRY CRITERIA:

* Diagnostically documented elevation in lactate, pyruvate, and/or alanine levels in lactic acidemia patients

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Richard H. Haas

Role: STUDY_CHAIR

University of California, San Diego

Locations

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University of California San Diego Medical Center

San Diego, California, United States

Site Status

Countries

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United States

Other Identifiers

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UCSD-071

Identifier Type: -

Identifier Source: secondary_id

NCRR-M01RR00827-0071