Trial Outcomes & Findings for Combination Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA (cT1-3, N0-1, M0) Breast Cancer and Positive Axillary Lymph Nodes (NCT NCT00003782)

NCT ID: NCT00003782

Last Updated: 2024-03-21

Results Overview

Recruitment status

COMPLETED

Study phase

PHASE3

Target enrollment

5351 participants

Primary outcome timeframe

8 years

Results posted on

2024-03-21

Participant Flow

Participant milestones

Participant milestones
Measure
Arm 1: Doxorubicin + Cyclophosphamide, Then Docetaxel
Doxorubicin + Cyclophosphamide, then Docetaxel
Arm 2: Doxorubicin + Docetaxel
Doxorubicin + Docetaxel
Arm 3: Doxorubicin + Docetaxel + Cyclophosphamide
Doxorubicin + Docetaxel + Cyclophosphamide
Overall Study
STARTED
1783
1784
1784
Overall Study
COMPLETED
1753
1753
1758
Overall Study
NOT COMPLETED
30
31
26

Reasons for withdrawal

Reasons for withdrawal
Measure
Arm 1: Doxorubicin + Cyclophosphamide, Then Docetaxel
Doxorubicin + Cyclophosphamide, then Docetaxel
Arm 2: Doxorubicin + Docetaxel
Doxorubicin + Docetaxel
Arm 3: Doxorubicin + Docetaxel + Cyclophosphamide
Doxorubicin + Docetaxel + Cyclophosphamide
Overall Study
No follow up data
30
31
26

Baseline Characteristics

Combination Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA (cT1-3, N0-1, M0) Breast Cancer and Positive Axillary Lymph Nodes

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
Doxorubicin + Cyclophosphamide, Then Docetaxel
n=1783 Participants
Doxorubicin + Cyclophosphamide, then Docetaxel
Doxorubicin + Docetaxel
n=1784 Participants
Doxorubicin + Docetaxel
Doxorubicin + Docetaxel + Cyclophosphamide
n=1784 Participants
Doxorubicin + Docetaxel + Cyclophosphamide
Total
n=5351 Participants
Total of all reporting groups
Age, Continuous
50 years
STANDARD_DEVIATION 9.8 • n=5 Participants
50 years
STANDARD_DEVIATION 9.5 • n=7 Participants
51 years
STANDARD_DEVIATION 9.9 • n=5 Participants
51 years
STANDARD_DEVIATION 9.7 • n=4 Participants
Sex: Female, Male
Female
1783 Participants
n=5 Participants
1784 Participants
n=7 Participants
1784 Participants
n=5 Participants
5351 Participants
n=4 Participants
Sex: Female, Male
Male
0 Participants
n=5 Participants
0 Participants
n=7 Participants
0 Participants
n=5 Participants
0 Participants
n=4 Participants

PRIMARY outcome

Timeframe: 8 years

Outcome measures

Outcome measures
Measure
Arm 1: Doxorubicin + Cyclophosphamide, Then Docetaxel
n=1753 Participants
Doxorubicin + Cyclophosphamide, then Docetaxel
Arm 2: Doxorubicin + Docetaxel
n=1753 Participants
Doxorubicin + Docetaxel
Arm 3: Doxorubicin + Docetaxel + Cyclophosphamide
n=1758 Participants
Doxorubicin + Docetaxel + Cyclophosphamide
Overall Survival
83 percentage of patients alive
79 percentage of patients alive
79 percentage of patients alive

PRIMARY outcome

Timeframe: time to event: breast cancer recurrence; second primary cancer; death from any cause as a first event

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: 9 years

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: baseline, 9 weeks, and 6, 12, 18, and 24 months

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: baseline, 9 weeks, and 6, 12, 18, and 24 months

Outcome measures

Outcome data not reported

Adverse Events

Doxorubicin + Cyclophosphamide, Then Docetaxel

Serious events: 66 serious events
Other events: 845 other events
Deaths: 0 deaths

Doxorubicin + Docetaxel

Serious events: 43 serious events
Other events: 561 other events
Deaths: 0 deaths

Doxorubicin + Docetaxel + Cyclophosphamide

Serious events: 46 serious events
Other events: 641 other events
Deaths: 0 deaths

Serious adverse events

Serious adverse events
Measure
Doxorubicin + Cyclophosphamide, Then Docetaxel
n=1748 participants at risk
Doxorubicin + Cyclophosphamide, then Docetaxel
Doxorubicin + Docetaxel
n=1748 participants at risk
Doxorubicin + Docetaxel
Doxorubicin + Docetaxel + Cyclophosphamide
n=1745 participants at risk
Doxorubicin + Docetaxel + Cyclophosphamide
Respiratory, thoracic and mediastinal disorders
Adult respiratory distress syndrome
0.11%
2/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Investigations
Alanine aminotransferase increased (ALT/SGPT)
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Immune system disorders
Anaphylaxis
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.17%
3/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Metabolism and nutrition disorders
Anorexia
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.11%
2/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Psychiatric disorders
Anxiety
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Investigations
Aspartate aminotransferase increased (AST/SGOT)
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.11%
2/1745
Participants at Risk includes any patient who submitted an AE form.
Investigations
Blood bilirubin increased
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Vascular disorders
Capillary leak syndrome
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Cardiac disorders
Cardiac disorders - Other, specify
0.17%
3/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Gastrointestinal disorders
Colitis
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.11%
2/1745
Participants at Risk includes any patient who submitted an AE form.
Cardiac disorders
Conduction disorder
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Psychiatric disorders
Confusion
0.11%
2/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Investigations
Creatinine increased
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Metabolism and nutrition disorders
Dehydration
0.11%
2/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.11%
2/1745
Participants at Risk includes any patient who submitted an AE form.
Psychiatric disorders
Depression
0.29%
5/1748
Participants at Risk includes any patient who submitted an AE form.
0.34%
6/1748
Participants at Risk includes any patient who submitted an AE form.
0.11%
2/1745
Participants at Risk includes any patient who submitted an AE form.
Gastrointestinal disorders
Diarrhea
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Gastrointestinal disorders
Duodenal ulcer
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Respiratory, thoracic and mediastinal disorders
Dyspnea
0.34%
6/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.17%
3/1745
Participants at Risk includes any patient who submitted an AE form.
Gastrointestinal disorders
Esophagitis
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Blood and lymphatic system disorders
Febrile neutropenia
0.11%
2/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.40%
7/1745
Participants at Risk includes any patient who submitted an AE form.
Gastrointestinal disorders
Gastrointestinal disorders - Other, specify
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
General disorders
General disorders and administration site conditions - Other, specify
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Renal and urinary disorders
Hematuria
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Hepatobiliary disorders
Hepatic failure
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Hepatobiliary disorders
Hepatobiliary disorders - Other, specify
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Metabolism and nutrition disorders
Hyperglycemia
0.80%
14/1748
Participants at Risk includes any patient who submitted an AE form.
0.29%
5/1748
Participants at Risk includes any patient who submitted an AE form.
0.11%
2/1745
Participants at Risk includes any patient who submitted an AE form.
Vascular disorders
Hypertension
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Metabolism and nutrition disorders
Hypertriglyceridemia
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Metabolism and nutrition disorders
Hypocalcemia
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Metabolism and nutrition disorders
Hypokalemia
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Metabolism and nutrition disorders
Hyponatremia
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Vascular disorders
Hypotension
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Respiratory, thoracic and mediastinal disorders
Hypoxia
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Infections and infestations
Infections and infestations - Other, specify
0.51%
9/1748
Participants at Risk includes any patient who submitted an AE form.
0.40%
7/1748
Participants at Risk includes any patient who submitted an AE form.
0.57%
10/1745
Participants at Risk includes any patient who submitted an AE form.
Nervous system disorders
Intracranial hemorrhage
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Gastrointestinal disorders
Mucositis oral
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Musculoskeletal and connective tissue disorders
Musculoskeletal and connective tissue disorder - Other, specify
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Cardiac disorders
Myocardial infarction
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Nervous system disorders
Nervous system disorders - Other, specify
0.11%
2/1748
Participants at Risk includes any patient who submitted an AE form.
0.23%
4/1748
Participants at Risk includes any patient who submitted an AE form.
0.11%
2/1745
Participants at Risk includes any patient who submitted an AE form.
Investigations
Neutrophil count decreased
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Nervous system disorders
Peripheral motor neuropathy
0.11%
2/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Respiratory, thoracic and mediastinal disorders
Pneumonitis
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Psychiatric disorders
Psychosis
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Respiratory, thoracic and mediastinal disorders
Respiratory, thoracic and mediastinal disorders - Other, specify
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Skin and subcutaneous tissue disorders
Stevens-Johnson syndrome
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Vascular disorders
Thromboembolic event
0.69%
12/1748
Participants at Risk includes any patient who submitted an AE form.
0.23%
4/1748
Participants at Risk includes any patient who submitted an AE form.
0.46%
8/1745
Participants at Risk includes any patient who submitted an AE form.
Gastrointestinal disorders
Typhlitis
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.17%
3/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Nervous system disorders
Vasovagal reaction
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Cardiac disorders
Ventricular arrhythmia
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.
Gastrointestinal disorders
Vomiting
0.11%
2/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Infections and infestations
Wound infection
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Investigations
White blood cell decreased
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Vascular disorders
Visceral arterial ischemia
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.11%
2/1745
Participants at Risk includes any patient who submitted an AE form.
Injury, poisoning and procedural complications
Dermatitis radiation
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.11%
2/1745
Participants at Risk includes any patient who submitted an AE form.
Renal and urinary disorders
Urinary tract obstruction
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.00%
0/1745
Participants at Risk includes any patient who submitted an AE form.
Cardiac disorders
Left ventricular systolic dysfunction
0.00%
0/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1748
Participants at Risk includes any patient who submitted an AE form.
0.06%
1/1745
Participants at Risk includes any patient who submitted an AE form.

Other adverse events

Other adverse events
Measure
Doxorubicin + Cyclophosphamide, Then Docetaxel
n=1748 participants at risk
Doxorubicin + Cyclophosphamide, then Docetaxel
Doxorubicin + Docetaxel
n=1748 participants at risk
Doxorubicin + Docetaxel
Doxorubicin + Docetaxel + Cyclophosphamide
n=1745 participants at risk
Doxorubicin + Docetaxel + Cyclophosphamide
Musculoskeletal and connective tissue disorders
Arthralgia
7.2%
126/1748
Participants at Risk includes any patient who submitted an AE form.
1.3%
22/1748
Participants at Risk includes any patient who submitted an AE form.
1.9%
33/1745
Participants at Risk includes any patient who submitted an AE form.
Gastrointestinal disorders
Diarrhea
4.5%
78/1748
Participants at Risk includes any patient who submitted an AE form.
3.8%
66/1748
Participants at Risk includes any patient who submitted an AE form.
6.4%
111/1745
Participants at Risk includes any patient who submitted an AE form.
General disorders
Fatigue
12.1%
212/1748
Participants at Risk includes any patient who submitted an AE form.
7.7%
135/1748
Participants at Risk includes any patient who submitted an AE form.
9.6%
167/1745
Participants at Risk includes any patient who submitted an AE form.
Blood and lymphatic system disorders
Febrile neutropenia
21.9%
383/1748
Participants at Risk includes any patient who submitted an AE form.
12.8%
223/1748
Participants at Risk includes any patient who submitted an AE form.
15.8%
275/1745
Participants at Risk includes any patient who submitted an AE form.
Infections and infestations
Infections and infestations - Other, specify
11.4%
200/1748
Participants at Risk includes any patient who submitted an AE form.
8.2%
144/1748
Participants at Risk includes any patient who submitted an AE form.
7.9%
137/1745
Participants at Risk includes any patient who submitted an AE form.
Musculoskeletal and connective tissue disorders
Myalgia
8.5%
148/1748
Participants at Risk includes any patient who submitted an AE form.
1.7%
29/1748
Participants at Risk includes any patient who submitted an AE form.
2.0%
35/1745
Participants at Risk includes any patient who submitted an AE form.
Gastrointestinal disorders
Nausea
9.3%
162/1748
Participants at Risk includes any patient who submitted an AE form.
7.3%
127/1748
Participants at Risk includes any patient who submitted an AE form.
8.9%
155/1745
Participants at Risk includes any patient who submitted an AE form.
Gastrointestinal disorders
Vomiting
8.0%
140/1748
Participants at Risk includes any patient who submitted an AE form.
5.1%
90/1748
Participants at Risk includes any patient who submitted an AE form.
6.8%
119/1745
Participants at Risk includes any patient who submitted an AE form.

Additional Information

Director, Division of Regulatory Affairs

NSABP Foundation, Inc.

Phone: 412-330-4600

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place

Restriction type: GT60