Irinotecan Plus Cyclosporine and Phenobarbital in Treating Patients With Solid Tumors or Lymphoma

NCT ID: NCT00002759

Last Updated: 2013-02-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 3 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 1996-06-30

Brief Summary

Phase I trial to study the effectiveness of irinotecan plus cyclosporine and phenobarbital in treating patients who have solid tumors or lymphoma that is refractory to standard therapy. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Cyclosporine and phenobarbital may enhance the effectiveness of irinotecan.

Detailed Description

OBJECTIVES:

I. Determine the maximum tolerated dose of irinotecan (CPT-11) when infused weekly with cyclosporine (CYSP) in patients with solid tumors or lymphoma refractory to standard therapy.

II. Determine whether CYSP modulates the pharmacokinetics and pharmacodynamics of CPT-11 and its active metabolite, SN-38.

III. Determine whether phenobarbital modulates the pharmacokinetics and pharmacodynamics of CPT-11 and SN-38.

OUTLINE: This is a dose escalation study of irinotecan. Patients are stratified according to gender.

Part I: Patients receive cyclosporine IV over 6 hours and irinotecan IV over 90 minutes weekly for 4 weeks. Courses repeat every 6 weeks in the absence of unacceptable toxicity or disease progression. Cohorts of 3-12 patients receive escalating doses of irinotecan until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose at which at least one third of patients experience dose limiting toxicity (DLT).

Part IIA: If the DLT is diarrhea in part I, then part IIA is opened. Patients receive oral phenobarbital, cyclosporine as in part I, and irinotecan at the MTD from part I. Dose escalation occurs as in part I to determine a new MTD. If the DLT continues to be diarrhea, the study is closed. Part IIB: If the DLT is neutropenia in part I, then part IIB is opened. Patients receive cyclosporine as in part I and escalating doses of irinotecan to determine a new MTD.

Part III: If the DLT is neutropenia in part IIA or any DLT in part IIB, patients receive phenobarbital, cyclosporine, and irinotecan at the MTD determined as in part IIA or part IIB. Dose escalation continues until a new MTD is determined.

Conditions

Drug/Agent Toxicity by Tissue/Organ; Lymphoma; Neutropenia; Small Intestine Cancer; Unspecified Adult Solid Tumor, Protocol Specific

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Arm I

See detailed description.

Group Type: EXPERIMENTAL

cyclosporine

Intervention Type: DRUG

irinotecan hydrochloride

Intervention Type: DRUG

phenobarbital

Intervention Type: DRUG

Interventions

cyclosporine

Intervention Type: DRUG

irinotecan hydrochloride

Intervention Type: DRUG

phenobarbital

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

DISEASE CHARACTERISTICS:

• Malignant solid tumor or lymphoma refractory to standard therapy or for which no therapy of proven benefit exists
• No leukemia
• Measurable or evaluable disease

PATIENT CHARACTERISTICS:

• Age: 18 and over
• Performance status: Karnofsky 70-100%
• Life expectancy: At least 3 months
• WBC at least 3,500/mm3
• Absolute neutrophil count at least 1,500/mm3
• Platelet count at least 100,000/mm3
• Hemoglobin at least 9 g/dL
• Bilirubin no greater than 1.5 mg/dL
• AST/ALT less than twice normal (unless due to disease)
• PT and PTT normal
• Creatinine no greater than 1.5 mg/dL
• Creatinine clearance at least 60 mL/min
• No history of congestive heart failure requiring medical therapy
• No clinically significant or life threatening cardiac arrhythmia
• No history of significant pulmonary disease or lymphangitic lung disease
• No hypersensitivity to cyclosporine or cremophore
• No history of manifest or latent porphyria or hypersensitivity to barbiturates (for parts of study using phenobarbital)
• No history of inflammatory bowel disease requiring therapy
• No chronic diarrhea syndrome or paralytic ileus
• No medical or psychiatric condition that precludes informed consent
• Not pregnant
• Effective contraception required of fertile women

PRIOR CONCURRENT THERAPY:

• At least 4 weeks since prior biologic therapy
• At least 2 weeks since prior colony stimulating factors
• At least 4 weeks since prior chemotherapy (at least 6 weeks since nitrosoureas or mitomycin)
• No prior bleomycin or irinotecan
• At least 4 weeks since prior radiotherapy to greater than 25% of bone marrow
• Minimum time interval between prior therapy and eligibility shortened by 2 weeks when phenobarbital is administered
• Concurrent use of medications that affect the central nervous or cardiovascular systems (e.g., anticonvulsants, calcium channel blockers, oral contraceptives) must be approved by the Principal Investigator

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Mark J. Ratain, MD

Role: STUDY_CHAIR

University of Chicago

Locations

University of Chicago Cancer Research Center

Chicago, Illinois, United States

Countries

United States

Other Identifiers

UCCRC-8033

Identifier Type: -

Identifier Source: secondary_id

NCI-T95-0100H

Identifier Type: -

Identifier Source: secondary_id

CDR0000064707

Identifier Type: REGISTRY

Identifier Source: secondary_id

NCI-2012-02242

Identifier Type: -

Identifier Source: org_study_id