Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders
NCT ID: NCT00001178
Last Updated: 2019-12-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
597 participants
OBSERVATIONAL
1981-01-19
2012-12-17
Brief Summary
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Detailed Description
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To continue the cross-sectional and longitudinal studies performed by the Cognitive Neuroscience Section of NINDS on the neuroanatomy, cerebral metabolism, neuropsychology, and genetics of frontotemporal dementia, corticobasal syndrome, and related brain disorders.
Study population
Frontal lobe dementias and atypical basal ganglia disorders including frontotemporal dementia, corticobasal syndrome, and related brain disorders.
Design
A cross-sectional assessment of neuropsychological, brain anatomical and metabolic function, and genetic measures in subjects with these disorders.
Outcome measures
MRI, FDG-PET, neuropsychological and clinical tests, genetics, and neuropathology.
Conditions
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Keywords
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Eligibility Criteria
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Inclusion Criteria
* Caregiver willing and able to accept the responsibilities involved in the study
Exclusion Criteria
* Behavioral symptoms that would preclude the gathering of data for the study
* Other medical or social condition that would preclude participation in the opinion of the investigators
18 Years
ALL
Yes
Sponsors
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National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Principal Investigators
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Eric M Wassermann, M.D.
Role: PRINCIPAL_INVESTIGATOR
National Institute of Neurological Disorders and Stroke (NINDS)
Locations
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National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
Countries
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References
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Schwartz M, Creasey H, Grady CL, DeLeo JM, Frederickson HA, Cutler NR, Rapoport SI. Computed tomographic analysis of brain morphometrics in 30 healthy men, aged 21 to 81 years. Ann Neurol. 1985 Feb;17(2):146-57. doi: 10.1002/ana.410170208.
Schlageter NL, Horwitz B, Creasey H, Carson R, Duara R, Berg GW, Rapoport SI. Relation of measured brain glucose utilisation and cerebral atrophy in man. J Neurol Neurosurg Psychiatry. 1987 Jun;50(6):779-85. doi: 10.1136/jnnp.50.6.779.
Duara R, Grady C, Haxby J, Ingvar D, Sokoloff L, Margolin RA, Manning RG, Cutler NR, Rapoport SI. Human brain glucose utilization and cognitive function in relation to age. Ann Neurol. 1984 Dec;16(6):703-13. doi: 10.1002/ana.410160613.
Other Identifiers
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81-N-0010
Identifier Type: -
Identifier Source: secondary_id
810010
Identifier Type: -
Identifier Source: org_study_id