A Pilot Study of Immunization With HIV-1 Antigen Pulsed Allogenic Dendritic Cells in HIV-Infected Asymptomatic Patients With CD4+ T Cells > 350 Cells/mm3
NCT ID: NCT00001064
Last Updated: 2016-12-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
INTERVENTIONAL
2005-06-30
Brief Summary
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Dendritic cells are a type of white blood cell used by the body to fight infection. They are instrumental in presenting antigens (such as HIV antigens) to the body's immune system. Since dendritic cells are not functioning maximally in HIV-infected patients, infusion of dendritic cells from an HIV-negative sibling may enable the affected sibling's immune system to recognize foreign particles more readily and increase immune response against the virus.
Detailed Description
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Dendritic cells from an HIV-negative sibling are obtained and treated with various viral proteins (HIV vaccines) or immunomodulators. The treated dendritic cells are infused into the HIV-infected patient monthly for 6 months. Siblings must be able to donate on multiple occasions, and patients are followed every 2-4 weeks during the study. Patients are screened over 3 months prior to study entry.
Conditions
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Keywords
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Study Design
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TREATMENT
Interventions
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Allogenic Dendritic Cells
Eligibility Criteria
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Inclusion Criteria
* HLA A2+.
* Same cell type as donor sibling.
* CD4 count \> 350 cells/mm3.
* HIV asymptomatic status.
* No HIV antivirals during study.
* Normal labs and chest x-ray.
Donor siblings must have:
* HLA A2+.
* HIV negativity.
* Ability to donate cells on multiple occasions.
* Negative status for hepatitis B and C.
Exclusion Criteria
Excluded:
* Antiviral therapy (unless CD4 count declines to \< 350 cells/mm3).
Prior Medication:
Excluded:
* Antiviral therapy within 90 days prior to study entry.
18 Years
ALL
No
Sponsors
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National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Locations
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Stanford Univ School of Medicine
Stanford, California, United States
Countries
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Other Identifiers
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SPIRAT 1
Identifier Type: -
Identifier Source: org_study_id