HIV Prevention Counseling for Men Who Have Sex With Men

NCT ID: NCT00000931

Last Updated: 2008-09-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

4350 participants

Study Classification

INTERVENTIONAL

Brief Summary

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The purpose of this study is to see if a behavioral intervention, a special kind of counseling, can reduce the risk of HIV infection in men who have sex with men. The behavioral intervention will be compared to the standard risk reduction counseling that is given before and after getting an HIV test.

In standard pre- and post-test counseling, everyone is told the same things about how to prevent HIV. The behavioral intervention used in this study is designed to help each individual prevent HIV according to his specific problems and needs.

Detailed Description

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The intervention being evaluated in this trial is based on the extensive literature on behavioral approaches to risk reduction in MSM. These reviews recommend an intervention that, unlike the current standard HIV pre-test and post-test risk-reduction counseling, is tailored to an individual's unique problems and needs, lifestyle, and situations that contribute to high-risk behavior. Furthermore, there is a need for HIV-prevention intervention trials using biological endpoints (e.g., HIV seroconversion) in addition to behavioral change indices.

Participants are randomly assigned to receive either the behavioral intervention or the control risk-reduction counseling. The same counseling staff provides the two types of treatment. The behavioral intervention consists of 10 counseling sessions within a 4-month period followed by quarterly maintenance sessions for the remainder of the 3-year follow-up. The intervention is conducted on a one-to-one basis and targets condom use, change in sexual practices associated with HIV risk, and change in sexual practices in the context of alcohol and drug use. Participants in the control group receive pre- and post-test counseling at enrollment, then semiannually through Month 36. Beginning at Month 6, all participants complete routine semiannual visits. At each visit, Risk Assessment and phlebotomy for specimen collection for HIV antibody tests are administered. As is routine in most public counseling and testing venues, participants in the control condition do not see the same counselor consistently.

Conditions

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HIV Infections

Keywords

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Homosexuality, Male Risk-Taking Behavior Therapy HIV Seronegativity

Study Design

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Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Interventions

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Behavioral intervention

Intervention Type BEHAVIORAL

Risk-reduction counseling

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

Participants may be eligible for this study if they:

* Are an HIV-negative man who has had anal sex with another man in the 12 months prior to study entry.
* Are able to attend all scheduled study visits.
* Are able to provide information for locator purposes (address, phone number, etc.).
* Are at least 18 years old.

Exclusion Criteria

Participants will not be eligible for this study if they:

* Have been in a monogamous relationship for 2 years or more with an HIV-negative man. (Monogamous is defined as a relationship in which the members of the couple engage in sexual activities with only each other.)
* Have an obvious mental disorder or any another condition that would prevent them from completing the study.
* Are currently enrolled in any Phase III HIV vaccine trial, including the AIDSVAX Phase III trial sponsored by VaxGen, Inc.
* Are currently enrolled in HIVNET Protocol 014.
* Were enrolled in the HIVNET 015 Pilot Study.
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Allergy and Infectious Diseases (NIAID)

NIH

Sponsor Role lead

Principal Investigators

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Chesney M, Coates T

Role: STUDY_CHAIR

Koblin B

Role: STUDY_CHAIR

Locations

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San Francisco Dept of Hlth / AIDS Office

San Francisco, California, United States

Site Status

Denver Dept of Public Health / HIVNET

Denver, Colorado, United States

Site Status

Howard Brown Health Ctr

Chicago, Illinois, United States

Site Status

Fenway Community Health Ctr

Boston, Massachusetts, United States

Site Status

New York Blood Ctr

The Bronx, New York, United States

Site Status

Univ of Washington

Seattle, Washington, United States

Site Status

Countries

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United States

References

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Koblin B, Chesney M, Coates T; EXPLORE Study Team. Effects of a behavioural intervention to reduce acquisition of HIV infection among men who have sex with men: the EXPLORE randomised controlled study. Lancet. 2004 Jul 3-9;364(9428):41-50. doi: 10.1016/S0140-6736(04)16588-4.

Reference Type RESULT
PMID: 15234855 (View on PubMed)

Other Identifiers

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HIVNET 015

Identifier Type: -

Identifier Source: org_study_id