Influence of Diet and Endurance Running on Intramuscular Lipids Measured at 4.1 TESLA

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Brief Summary

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The purpose of this pilot investigation is to use 1 H Magnetic Resonance Spectroscopy (MRS) to 1) document the change in intra-muscular lipid stores (IML) before and after a prolonged bout of endurance running and, 2) determine the pattern (time course) of IML replenishment following an extremely low-fat diet (10% of energy from fat) and a moderate-fat diet (35% of energy from fat). Specifically, the study will evaluate the change in IML following a 2-hour training run and the recovery of IML in response to the post-exercise low-fat or moderate-fat diet in 10 endurance trained athletes who will consume both diets in a randomly assigned cross-over fashion. We hypothesize that IML will be depleted with prolonged endurance exercise, and that replenishment of IML will be impaired by an extremely low-fat diet compared to a moderate-fat diet. Results of this pilot study will be used to apply for extramural grant support from NIH or the US Armed Forces to investigate the effect of dietary fat on the health and performance of individuals performing heavy physical training. It is anticipated that this methodology could also be employed in obesity research to delineate, longitudinally, the reported cross-sectional relationships among IML stores, insulin resistance and obesity.

Detailed Description

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Conditions

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Obesity

Study Design

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Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Interventions

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magnetic resonance spectroscopy

Intervention Type PROCEDURE

dietary fat

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy volunteers (developmental phase)
* Healthy endurance-trained subjects
* Maximum age for males is 39
* Maximum age for females is 49

Minimum Eligible Age

18 Years

Maximum Eligible Age

49 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Locations

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The University of Alabama at Birmingham Nutrition Sciences Department

Birmingham, Alabama, United States

Site Status

Countries

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United States

Other Identifiers

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M01RR000032

Identifier Type: NIH

Identifier Source: secondary_id

View Link

NCRR-M01RR00032-0855

Identifier Type: -

Identifier Source: org_study_id